Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China

  • Ni, Wei (Neurosurgery Department of Yunnan Tumor Hospital & The Third Affiliated Hospital of Kunming Medical University) ;
  • Luo, Lin (Neurosurgery Department of Yunnan Tumor Hospital & The Third Affiliated Hospital of Kunming Medical University) ;
  • Ping, Zuo (Neurosurgery Department of Yunnan Tumor Hospital & The Third Affiliated Hospital of Kunming Medical University) ;
  • Yuan, Hong-Ping ;
  • Zhao, Xu-Dong (Kunming Institute of Zoology, Chinese Academy of Sciences) ;
  • Xu, Wei (The Second Affiliated Hospital of Kunming Medical University)
  • Published : 2015.02.25
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Abstract

Background: Aberrations in gene methylation patterns play important roles in gliomagenesis. However, whether the ALDH1A3 promoter methylation is related to prognoses of primary glioblastomas (GBMs) in Western China remains unclear. Materials and Methods: Methylation levels of ALDH1A3 CpG island in 36 GBMs were identified by pyrophosphate sequencing, while ALDH1A3 expression was assessed with matched paraffin section immunohistochemistry. Survival curves were analysed by Kaplan-Meier. Results: The hypermethylation status of ALDH1A3 promoter predicted a better prognosis accompanied with low expression of ALDH1A3 protein. Conclusions: Our results indicate ALDH1A3 promoter methylation correlates with prognosis in primary GBMs.

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References

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