한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제28권1호
  • /
  • Pages.53-67
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  • 2015
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  • 1738-6640(pISSN)
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  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
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가미자운고(加味紫雲膏)가 mouse의 피부화상 치료에 대한 분자생물학적 효과 및 기전연구

Effects of Gamijaungo on the burn mice model and the study of hematologic, pathologic and molecular mechanism

  • 이종철 (가천대학교 한의과대학 한방안이비인후피부과) ;
  • 김경준 (가천대학교 한의과대학 한방안이비인후피부과)
  • Lee, Jong-Chul (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University) ;
  • Kim, Gyung-Jun (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
  • 투고 : 2015.01.07
  • 심사 : 2015.02.04
  • 발행 : 2015.02.25
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초록

Objective: The aim of this study was to investigate the wound healing effect of herbal ointment, Gamijaungo, on the burn-induced model. Reports about Gamijaungo on the wound healing effect by local application in mice model or human study have published in the several domestic or internationally, but most are anecdotal and lack solid scientific evidence. Method: We observed the morphologic and histologic changes in the burn-induced mice model. we counted white blood cell and platelet changes. we confirmed VEGF, PI3K and pAkt protein expression by Western blot analysis. Result: In this study, we observed that Gamijaungo showed strong wound healing effects in the morphologic and histologic changes in the burn-induced mice model. Also we found that the significant changes of white blood cell and platelet changes by the treatment of Gamijaungo. In molecular mechanism, we got the strong positive effect by Gamijaungo treatment on angiogenesis, a key process in the formation of the granulation tissue during wound healing. Conclusion: These findings suggest the potential use of Gamijaungo as a therapeutic in thermal burn-induced skin injuries.

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