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Imaging Features of Madelung's Disease: Case Report

  • Kang, Hyun Jung (Department of Radiology, Pusan National University Hospital, Biomedical Research Institute) ;
  • Lee, In Sook (Department of Radiology, Pusan National University Hospital, Biomedical Research Institute) ;
  • Cha, Won Jae (Department of Otorhinolaryngology, Pusan National University Hospital) ;
  • Kim, Hak Jin (Department of Radiology, Pusan National University Hospital, Biomedical Research Institute) ;
  • Song, You Seon (Department of Radiology, Pusan National University Hospital, Biomedical Research Institute) ;
  • Ko, Jin Young (Department of Otorhinolaryngology, Pusan National University Hospital)
  • Received : 2015.05.08
  • Accepted : 2015.06.14
  • Published : 2015.06.30

Abstract

Madelung's disease, or benign symmetric lipomatosis, is an uncommon disorder that is characterized by massive symmetrical deposits of adipose tissue in the upper trunk, neck and head, and is usually associated with alcohol abuse; as such, patients usually complain of cosmetic issues. Historically, Madelung's disease is usually encountered in men between 30 and 60 years of age, and is more prevalent in the Mediterranean population. In this case study, we describe a rare case of Madelung's disease, in an Asian patient who presented with symmetrically located bilateral masses in the anterior neck, which grew progressively larger over a period of seven years.

Keywords

References

  1. Bulum T, Duvnjak L, Car N, Metelko Z. Madelung's disease: case report and review of the literature. Diabetologia Croatica 2007;36:25-30
  2. Milisavljevic D, Zivic M, Radovanovic Z, Stankovic P. Severe dyspnea as atypical presenting symptom of Madelung's disease. Hippokratia 2010;14:133-135
  3. Brea-Garcia B, Cameselle-Teijeiro J, Couto-Gonzalez I, Taboada-Suarez A, Gonzalez-Alvarez E. Madelung's disease: comorbidities, fatty mass distribution, and response to treatment of 22 patients. Aesthetic Plast Surg 2013;37:409-416 https://doi.org/10.1007/s00266-012-9874-5
  4. Landis MS, Etemad-Rezai R, Shetty K, Goldszmidt M. Case 143: Madelung disease. Radiology 2009;250:951-954 https://doi.org/10.1148/radiol.2503071024
  5. Ruzicka T, Vieluf D, Landthaler M, Braun-Falco O. Benign symmetric lipomatosis Launois-Bensaude. Report of ten cases and review of the literature. J Am Acad Dermatol 1987;17:663-674 https://doi.org/10.1016/S0190-9622(87)70253-9
  6. Becker-Wegerich P, Steuber M, Olbrisch R, Ruzicka T, Auburger G, Hofhaus G. Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis. Arch Dermatol Res 1998;290:652-655 https://doi.org/10.1007/s004030050368
  7. Yeh NC, Yang CY, Chou CW, Yen FC, Lee SY, Tien KJ. Madelung's disease. J Clin Endocrinol Metab 2012;97:3012-3013 https://doi.org/10.1210/jc.2012-1649
  8. Klopstock T, Naumann M, Schalke B, et al. Multiple symmetric lipomatosis: abnormalities in complex IV and multiple deletions in mitochondrial DNA. Neurology 1994;44:862-866 https://doi.org/10.1212/WNL.44.5.862
  9. Berkovic SF, Andermann F, Shoubridge EA, et al. Mitochondrial dysfunction in multiple symmetrical lipomatosis. Ann Neurol 1991;29:566-569 https://doi.org/10.1002/ana.410290519
  10. Zhang XY, Li NY, Xiao WL. Madelung disease: manifestations of CT and MR imaging. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e57-64
  11. Smith PD, Stadelmann WK, Wassermann RJ, Kearney RE. Benign symmetric lipomatosis (Madelung's disease). Ann Plast Surg 1998;41:671-673 https://doi.org/10.1097/00000637-199812000-00016
  12. Gologorsky Y, Gologorsky D, Yarygina AS, Surti U, Zirwas MJ. Familial multiple lipomatosis: report of a new family. Cutis 2007;79:227-232

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  1. Madelung's Disease: Lipectomy or Liposuction? vol.2018, pp.None, 2018, https://doi.org/10.1155/2018/3975974