Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
권호 표지
DOI QR코드

DOI QR Code

MR Imaging Findings of Tamoxifen-associated Uterine Adenosarcoma: Report of Two Cases

  • Choi, Soo Yeon (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Sung, Deuk Jae (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Han, Na Yeon (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Park, Beom Jin (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Kim, Min Ju (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Sim, Ki Choon (Department of Radiology, Anam Hospital, College of Medicine, Korea University) ;
  • Cho, Sung Bum (Department of Radiology, Anam Hospital, College of Medicine, Korea University)
  • Received : 2015.02.26
  • Accepted : 2015.03.25
  • Published : 2015.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Adenosarcoma of the uterus is a rare biphasic tumor containing benign glandular epithelial and malignant mesenchymal components. The tumor has been reported to be associated with antiestrogen therapy, particularly tamoxifen, but there have been a few case reports with MRI. We present two cases of MRI findings of uterine adenosarcoma after antiestrogen therapy, tamoxifen and toremifene in breast cancer patients. The tumor presents as a large polypoid mass occupying the endometrial cavity, and may protrude into the vagina. On MRI, the tumor typically shows solid components with scattered small cysts and heterogeneous enhancement. These findings are not significantly different from conventional adenosarcoma.

Keywords

References

  1. Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol 1990;21:363-381 https://doi.org/10.1016/0046-8177(90)90198-E
  2. Chourmouzi D, Boulogianni G, Zarampoukas T, Drevelengas A. Sonography and MRI of tamoxifen-associated mullerian adenosarcoma of the uterus. AJR Am J Roentgenol 2003;181:1673-1675 https://doi.org/10.2214/ajr.181.6.1811673
  3. Yoshizako T, Wada A, Kitagaki H, Ishikawa N, Miyazaki K. MR imaging of uterine adenosarcoma: case report and literature review. Magn Reson Med Sci 2011;10:251-254 https://doi.org/10.2463/mrms.10.251
  4. Lee HK, Kim SH, Cho JY, Yeon KM. Uterine adenofibroma and adenosarcoma: CT and MR findings. J Comput Assist Tomogr 1998;22:314-316 https://doi.org/10.1097/00004728-199803000-00030
  5. Soh E, Eleti A, Jimenez-Linan M, Arends M, Latimer J, Sala E. Magnetic resonance imaging findings of tamoxifenassociated uterine Mullerian adenosarcoma: a case report. Acta Radiol 2008;49:848-851
  6. Takeuchi M, Matsuzaki K, Yoshida S, et al. Adenosarcoma of the uterus: magnetic resonance imaging characteristics. Clin Imaging 2009;33:244-247 https://doi.org/10.1016/j.clinimag.2008.11.003
  7. Chi F, Wu R, Zeng Y, Xing R, Liu Y, Xu Z. Effects of toremifene versus tamoxifen on breast cancer patients: a meta-analysis. Breast Cancer 2013;20:111-122 https://doi.org/10.1007/s12282-012-0430-6
  8. Clement PB. Mullerian adenosarcomas of the uterus with sarcomatous overgrowth. A clinicopathological analysis of 10 cases. Am J Surg Pathol 1989;13:28-38 https://doi.org/10.1097/00000478-198901000-00004
  9. Nalaboff KM, Pellerito JS, Ben-Levi E. Imaging the endometrium: disease and normal variants. Radiographics 2001;21:1409-1424 https://doi.org/10.1148/radiographics.21.6.g01nv211409
  10. Shah SH, Jagannathan JP, Krajewski K, O'Regan KN, George S, Ramaiya NH. Uterine sarcomas: then and now. AJR Am J Roentgenol 2012;199:213-223 https://doi.org/10.2214/AJR.11.7287