Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis

  • Yang, Qing-Li (National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention/ Key Laboratory of Parasite and Vector Biology, Ministry of Health/ WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis) ;
  • Shen, Ji-Qing (Department of Parasitology, Guangxi Medical University) ;
  • Xue, Yan (Department of Parasitology, Guangxi Medical University) ;
  • Cheng, Xiao-Bing (Department of Parasitology, Guangxi Medical University) ;
  • Jiang, Zhi-Hua (Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control/ Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis) ;
  • Yang, Yi-Chao (Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control/ Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis) ;
  • Chen, Ying-Dan (National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention/ Key Laboratory of Parasite and Vector Biology, Ministry of Health/ WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis) ;
  • Zhou, Xiao-Nong (National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention/ Key Laboratory of Parasite and Vector Biology, Ministry of Health/ WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis)
  • Received : 2015.01.14
  • Accepted : 2015.08.24
  • Published : 2015.12.31
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Abstract

The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.

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References

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