Journal of Yeungnam Medical Science
- 제32권2호
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- Pages.138-142
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- 2015
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- 2799-8010(eISSN)
DOI QR Code
Metastatic papillary thyroid cancers with malignant pleural effusion aggravated during thyroid hormone withdrawal for radioiodine therapy
- Seo, Ji Hye (Department of Internal Medicine, Korea University College of Medicine) ;
- Je, Ji Hye (Department of Internal Medicine, Korea University College of Medicine) ;
- Lee, Hyun Jung (Department of Internal Medicine, Korea University College of Medicine) ;
- Na, Young Ju (Department of Internal Medicine, Korea University College of Medicine) ;
- Jeong, Il Woo (Department of Internal Medicine, Korea University College of Medicine) ;
- An, Jee Hyun (Department of Internal Medicine, Korea University College of Medicine) ;
- Kim, Sin Gon (Department of Internal Medicine, Korea University College of Medicine) ;
- Choi, Dong Seop (Department of Internal Medicine, Korea University College of Medicine) ;
- Kim, Nam Hoon (Department of Internal Medicine, Korea University College of Medicine)
- 투고 : 2014.07.16
- 심사 : 2014.09.22
- 발행 : 2015.12.31
초록
L-thyroxine (LT4) withdrawal prior to radioactive iodine (RAI) ablation therapy is a commonly used method for successful treatment of patients with papillary thyroid cancer (PTC). However, a prolonged period of hypothyroidism induced by LT4 withdrawal is sometimes associated with impaired quality of life and cardiopulmonary dysfunction in PTC patients. Furthermore, LT4 withdrawal may have a trophic effect on residual cancer by means of increased thyrotropin. We report on 2 cases of metastatic PTC patients with malignant pleural effusion (MPE) whose disease showed rapid worsening after LT4 withdrawal and RAI therapy. The first case is a 65-year-old woman who had PTC with multiple distant metastases and MPE. During LT4 withdrawal for RAI therapy, MPE showed rapid worsening, and the patient required repetitive therapeutic thoracentesis. The second case is a 49-year-old woman with PTC who underwent 3 additional operations for cancer recurrence in the neck lymph nodes and 6 times of RAI treatments. While preparing for the