YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Anti-inflammatory Effects of Staphylea bumalda Leaves Extracts in Murine Macrophages

쥐 대식세포에 대한 고추나무(Staphylea bumalda) 잎의 항염증 효과 검증

  • Kim, Jeong Hwa (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jae Kwon (Department of Biology Education, College of Education, Chungbuk National University)
  • 김정화 (충북대학교 약학대학) ;
  • 이재권 (충북대학교 사범대학 생물교육과)
  • Received : 2015.09.22
  • Accepted : 2015.10.29
  • Published : 2015.12.31
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Abstract

Aim of the present study was to investigate whether methanol extract from the leaves of Staphylea bumalda could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines, Raw 264.7 cells. The extract reduced nitric oxide (NO), cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines production from LPS-stimulated Raw 264.7 cells. These inhibitory effects were associated with decreases in the phosphorylation of MAP kinases and the activity of $NF{\kappa}B$ signal pathways. Our results indicate that Staphylea bumalda significantly inhibits the inflammatory activity of activated macrophages, suggesting that Staphylea bumalda could be a potential candidate for the treatment of inflammatory disease.

Keywords

References

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