Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Current state and prospective of the Korean medical research on the cancer metabolism

암특이적 대사에 대한 한의학적 연구의 현황 및 전망

  • Chung, Tae-Wook (Korean Medical Research Center for Healthy Aging, Pusan National University) ;
  • Kim, Eun-Yeong (Korean Medical Research Center for Healthy Aging, Pusan National University) ;
  • Choi, Hee-Jin (Korean Medical Research Center for Healthy Aging, Pusan National University) ;
  • Choi, Hee-Jung (Korean Medical Research Center for Healthy Aging, Pusan National University) ;
  • Ha, Ki-Tae (Korean Medical Research Center for Healthy Aging, Pusan National University)
  • 정태욱 (부산대학교 건강노화 한의과학 연구센터) ;
  • 김은영 (부산대학교 건강노화 한의과학 연구센터) ;
  • 최희진 (부산대학교 건강노화 한의과학 연구센터) ;
  • 최희정 (부산대학교 건강노화 한의과학 연구센터) ;
  • 하기태 (부산대학교 건강노화 한의과학 연구센터)
  • Received : 2015.03.28
  • Accepted : 2015.04.20
  • Published : 2015.04.25
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Abstract

Generally, normal cells synthesize adenosine triphosphate (ATP) through oxidative phosphorylation in the mitochondria. However, they produce ATP through lactic acid fermentation on hypoxic condition. Interestingly, many cancer cells rely on aerobic glycolysis for ATP generation instead of mitochondrial oxidative phosphorylation, which is termed as "Warburg effect". According to results from recent researches on differences of cancer cell metabolism from normal cell metabolism and because chemotherapy to suppress rapidly growing cells, as a side effect of cancer treatment, can still target healthy cells, there is merit in the development of small-molecule inhibitors targeting metabolic enzymes such as pyruvate dehydrogenase kinase (PDHK), lactate dehydrogenase (LDH) and monocarboxylate transporter (MCT). For new anticancer therapy, in this review, we show recent advances in study on cancer cell metabolism and molecules targeting metabolic enzymes which are importantly associated with cancer metabolism for cancer therapy. Furthermore, we would also like to emphasize the necessity of development of molecules targeting metabolic enzymes using herbal medicines and their constituents for anticancer drugs.

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References

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