Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Blood-compatible Bio-inspired Surface of Poly(L-lactide-co-ε-caprolactone) Films Prepared Using Poor Co-solvent Casting

비용매 휘발법을 이용한 생체모사 혈액친화성 폴리락티드-카프로락톤 공중합체 필름의 제조

  • Lim, Jin Ik (Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University) ;
  • Kim, Soo Hyun (Division of Life and Health Sciences, Biomaterials Research Center, Korea Institute of Science and Technology)
  • 임진익 (단국대학교 화학공학과) ;
  • 김수현 (한국과학기술연구원 생체재료연구단)
  • Received : 2014.05.12
  • Accepted : 2014.07.03
  • Published : 2015.01.25
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Abstract

Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-${\varepsilon}$-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaflike-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately $124^{\circ}$. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.

혈항혈전성 표면의 제조를 위해 간단한 비용매 휘발 방법을 통하여 고탄성체이면서 생분해성 폴리 락티드-카프로락톤 공중합체 필름의 표면상에 연잎 구조물과 유사한 마이크로 돌기를 만들어 주었다. 표면 구조와 소수성도, 항혈전 효과 등을 시험했으며, 결정화도와 탄성회복률 등의 물리적 특성도 분석하였다. 그 결과 비용매와 메틸렌클로라이드의 혼합 부피비 1:2에서 연잎표면과 유사한 최적의 효과를 얻었으며, 이때 수접촉각은 $124^{\circ}$였다. 혈소판 부착시험에서는 처리하지 않는 군에 비해 약 10%만 부착되는 효과를 확인할 수 있었다.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

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