Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy

  • Yoon, Ji Hyun (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Son, Jung Woo (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chung, Hyemoon (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Chul Hwan (Department of Radiology, Yonsei University College of Medicine) ;
  • Kim, Young-Jin (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Hyuk-Jae (Department of Radiology, Yonsei University College of Medicine) ;
  • Hong, Geu-Ru (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Tae Hoon (Department of Radiology, Yonsei University College of Medicine) ;
  • Ha, Jong-Won (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, Byoung Wook (Department of Radiology, Yonsei University College of Medicine) ;
  • Rim, Se-Joong (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chung, Namsik (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, Eui-Young (Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine)
  • Received : 2015.02.07
  • Accepted : 2015.06.30
  • Published : 2015.09.01
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Abstract

Objective: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). Materials and Methods: Fifty-nine patients with DCM (mean age, $55{\pm}15years$; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. Results: The mean LV ejection fraction was $24{\pm}9%$ and the post-T1 value was $254.5{\pm}46.4ms$. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (${\beta}$ = -0.351, p = 0.016) and the LV mass/volume ratio (${\beta}$ = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (${\beta}$ = -0.339, p = 0.017). Conclusion: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.

Keywords

References

  1. Jessup M, Brozena S. Heart failure. N Engl J Med 2003;348:2007-2018 https://doi.org/10.1056/NEJMra021498
  2. Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, et al. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2008;29:270-276
  3. Roger VL, Weston SA, Redfield MM, Hellermann-Homan JP, Killian J, Yawn BP, et al. Trends in heart failure incidence and survival in a community-based population. JAMA 2004;292:344-350 https://doi.org/10.1001/jama.292.3.344
  4. Rihal CS, Nishimura RA, Hatle LK, Bailey KR, Tajik AJ. Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis. Circulation 1994;90:2772-2779 https://doi.org/10.1161/01.CIR.90.6.2772
  5. Pinamonti B, Zecchin M, Di Lenarda A, Gregori D, Sinagra G, Camerini F. Persistence of restrictive left ventricular filling pattern in dilated cardiomyopathy: an ominous prognostic sign. J Am Coll Cardiol 1997;29:604-612 https://doi.org/10.1016/S0735-1097(96)00539-6
  6. Doust JA, Pietrzak E, Dobson A, Glasziou P. How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review. BMJ 2005;330:625 https://doi.org/10.1136/bmj.330.7492.625
  7. Kwon DH, Halley CM, Carrigan TP, Zysek V, Popovic ZB, Setser R, et al. Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study. JACC Cardiovasc Imaging 2009;2:34-44 https://doi.org/10.1016/j.jcmg.2008.09.010
  8. Rudolph A, Abdel-Aty H, Bohl S, Boyé P, Zagrosek A, Dietz R, et al. Noninvasive detection of fibrosis applying contrastenhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol 2009;53:284-291 https://doi.org/10.1016/j.jacc.2008.08.064
  9. Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrastenhanced T1 mapping. J Am Coll Cardiol 2008;52:1574-1580 https://doi.org/10.1016/j.jacc.2008.06.049
  10. Karaahmet T, Tigen K, Dundar C, Pala S, Guler A, Kilicgedik A, et al. The effect of cardiac fibrosis on left ventricular remodeling, diastolic function, and N-terminal pro-B-type natriuretic peptide levels in patients with nonischemic dilated cardiomyopathy. Echocardiography 2010;27:954-960 https://doi.org/10.1111/j.1540-8175.2010.01170.x
  11. Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol 2011;57:891-903 https://doi.org/10.1016/j.jacc.2010.11.013
  12. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440-1463 https://doi.org/10.1016/j.echo.2005.10.005
  13. Severino S, Caso P, Galderisi M, De Simone L, Petrocelli A, de Divitiis O, et al. Use of pulsed Doppler tissue imaging to assess regional left ventricular diastolic dysfunction in hypertrophic cardiomyopathy. Am J Cardiol 1998;82:1394-1398 https://doi.org/10.1016/S0002-9149(98)00648-1
  14. Quiñones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA; Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr 2002;15:167-184 https://doi.org/10.1067/mje.2002.120202
  15. Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quiñones MA. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-1533 https://doi.org/10.1016/S0735-1097(97)00344-6
  16. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 2005;112:2254-2262 https://doi.org/10.1161/CIRCULATIONAHA.105.541078
  17. Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS, et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation 1992;86:513-521 https://doi.org/10.1161/01.CIR.86.2.513
  18. McCrohon JA, Moon JC, Prasad SK, McKenna WJ, Lorenz CH, Coats AJ, et al. Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance. Circulation 2003;108:54-59 https://doi.org/10.1161/01.CIR.0000078641.19365.4C
  19. Park S, Choi BW, Rim SJ, Shim CY, Ko YG, Kang SM, et al. Delayed hyperenhancement magnetic resonance imaging is useful in predicting functional recovery of nonischemic left ventricular systolic dysfunction. J Card Fail 2006;12:93-99 https://doi.org/10.1016/j.cardfail.2005.10.003
  20. Amano Y, Takayama M, Kumita S. Contrast-enhanced myocardial T1-weighted scout (Look-Locker) imaging for the detection of myocardial damages in hypertrophic cardiomyopathy. J Magn Reson Imaging 2009;30:778-784 https://doi.org/10.1002/jmri.21921
  21. Karlsson M, Nordell B. Analysis of the Look-Locker T(1) mapping sequence in dynamic contrast uptake studies: simulation and in vivo validation. Magn Reson Imaging 2000;18:947-954 https://doi.org/10.1016/S0730-725X(00)00193-4
  22. Alter P, Rupp H, Stoll F, Adams P, Figiel JH, Klose KJ, et al. Increased end diastolic wall stress precedes left ventricular hypertrophy in dilative heart failure--use of the volume-based wall stress index. Int J Cardiol 2012;157:233-238 https://doi.org/10.1016/j.ijcard.2011.07.092
  23. White SK, Sado DM, Flett AS, Moon JC. Characterising the myocardial interstitial space: the clinical relevance of noninvasive imaging. Heart 2012;98:773-779 https://doi.org/10.1136/heartjnl-2011-301515
  24. Nacif MS, Turkbey EB, Gai N, Nazarian S, van der Geest RJ, Noureldin RA, et al. Myocardial T1 mapping with MRI: comparison of look-locker and MOLLI sequences. J Magn Reson Imaging 2011;34:1367-1373 https://doi.org/10.1002/jmri.22753
  25. Ho CY, Abbasi SA, Neilan TG, Shah RV, Chen Y, Heydari B, et al. T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy. Circ Cardiovasc Imaging 2013;6:415-422 https://doi.org/10.1161/CIRCIMAGING.112.000333
  26. Pinamonti B, Di Lenarda A, Sinagra G, Camerini F. Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: clinical, echocardiographic and hemodynamic correlations and prognostic implications. Heart Muscle Disease Study Group. J Am Coll Cardiol 1993;22:808-815 https://doi.org/10.1016/0735-1097(93)90195-7
  27. Choi EY, Choi BW, Kim SA, Rhee SJ, Shim CY, Kim YJ, et al. Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy. Eur J Heart Fail 2009;11:573-580 https://doi.org/10.1093/eurjhf/hfp050
  28. Tham EB, Haykowsky MJ, Chow K, Spavor M, Kaneko S, Khoo NS, et al. Diffuse myocardial fibrosis by T1-mapping in children with subclinical anthracycline cardiotoxicity: relationship to exercise capacity, cumulative dose and remodeling. J Cardiovasc Magn Reson 2013;15:48 https://doi.org/10.1186/1532-429X-15-48
  29. Creemers EE, Pinto YM. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 2011;89:265-272 https://doi.org/10.1093/cvr/cvq308
  30. Tsuruda T, Boerrigter G, Huntley BK, Noser JA, Cataliotti A, Costello-Boerrigter LC, et al. Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ Res 2002;91:1127-1134 https://doi.org/10.1161/01.RES.0000046234.73401.70

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