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Sonography of Invasive Apocrine Carcinoma of the Breast in Five Cases

  • Seo, Kyung-Jin (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • An, Yeong Yi (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Whang, In Yong (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Chang, Eun Deok (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Kang, Bong Joo (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Kim, Sung Hun (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Park, Chang Suk (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Kim, Jeong Soo (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
  • Hong, Hyunjoo (Department of Radiology, College of Medicine, The Catholic University of Korea)
  • Received : 2015.04.20
  • Accepted : 2015.06.13
  • Published : 2015.09.01

Abstract

Objective: To evaluate the sonographic features of invasive apocrine carcinoma (IAC) of the breast. Materials and Methods: This study included five pathologically proven cases of IAC, and their sonographic features were retrospectively analyzed according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon. Results: All five lesions involved the left breast and were seen as irregularly shaped masses. All lesions, except one, had a parallel orientation to the chest wall. All five lesions showed noncircumscribed margins and heterogeneous echotexture; however, they showed various posterior features. One lesion had edema as an associated feature. Sonographic assessments were classified as BI-RADS category 4 in all five cases. Conclusion: Invasive apocrine carcinoma sonographic findings are difficult to differentiate from those of invasive ductal carcinoma of no special type.

Keywords

References

  1. Krompecher E. Zur Histogenese und Morphologie der Cystenmamma (maladie kystique reclus, cystadenoma Schimmelbuscin, mastitis chronica cystica Konig) des intrakanalikularen Kystadenomas und der Kystadenokarzinome der Brustdruse (Hidrokystoma, kystadenoma, Hidrokystadenocarzinoma mammae). Beitr Pathol Anat 1916;62:403-410
  2. Eusebi V, Millis RR, Cattani MG, Bussolati G, Azzopardi JG. Apocrine carcinoma of the breast. A morphologic and immunocytochemical study. Am J Pathol 1986;123:532-541
  3. Bhargava R. Apocrine carcinoma of the breast. In: Dabbs DJ, ed. Breast pathology. Philadelphia, PA: Elsevier/Saunders, 2012:502-511
  4. Onoue S, Katoh T, Chigira H, Matsuo K, Suzuki M, Shibata Y, et al. A Case of Apocrine Carcinoma of the Breast Presenting as Two Cysts. Breast Cancer 1997;4:193-196 https://doi.org/10.1007/BF02967076
  5. Gokalp G, Topal U, Haholu A, Kizilkaya E. Apocrine carcinoma of the breast: mammography and ultrasound findings. Eur J Radiol Extra 2006;60:55-59 https://doi.org/10.1016/j.ejrex.2006.08.004
  6. Mendelson EB, Böhm-Velez M, Berg WA. ACR BI-RADS Ultrasound. In: American College of Radiology, ed. ACR BI-RADS breast imaging and reporting data system. 5th ed. Reston, VA: American College of Radiology, 2013
  7. Azzopardi JG, Ahmed A, Millis RR. Problems in breast pathology. Philadelphia: Saunders, 1979:57-67, 341-344
  8. Vranic S, Schmitt F, Sapino A, Costa JL, Reddy S, Castro M, et al. Apocrine carcinoma of the breast: a comprehensive review. Histol Histopathol 2013;28:1393-1409
  9. Gilles R, Lesnik A, Guinebretière JM, Tardivon A, Masselot J, Contesso G, et al. Apocrine carcinoma: clinical and mammographic features. Radiology 1994;190:495-497 https://doi.org/10.1148/radiology.190.2.8284405
  10. Yuen S, Uematsu T, Kasami M, Tanaka K, Kimura K, Sanuki J, et al. Breast carcinomas with strong high-signal intensity on T2-weighted MR images: pathological characteristics and differential diagnosis. J Magn Reson Imaging 2007;25:502-510 https://doi.org/10.1002/jmri.20845
  11. Kuroki-Suzuki S, Kuroki Y, Nasu K, Nawano S, Moriyama N, Okazaki M. Detecting breast cancer with non-contrast MR imaging: combining diffusion-weighted and STIR imaging. Magn Reson Med Sci 2007;6:21-27 https://doi.org/10.2463/mrms.6.21
  12. Hirose M, Hashizume T, Seino N, Kubota H, Nobusawa H, Gokan T. Atlas of breast magnetic resonance imaging. Curr Probl Diagn Radiol 2007;36:51-65 https://doi.org/10.1067/j.cpradiol.2006.10.003
  13. Tavassoli FA, Purcell CA, Bratthauer GL, Man YG. Androgen receptor expression along with loss of bcl-2, ER, and PR expression in benign and malignant apocrine lesions of the breast: implications for therapy. Breast J 1996;2:261-269 https://doi.org/10.1111/j.1524-4741.1996.tb00107.x
  14. Mazoujian G, Bodian C, Haagensen DE Jr, Haagensen CD. Expression of GCDFP-15 in breast carcinomas. Relationship to pathologic and clinical factors. Cancer 1989;63:2156-2161 https://doi.org/10.1002/1097-0142(19890601)63:11<2156::AID-CNCR2820631115>3.0.CO;2-B
  15. Honma N, Takubo K, Akiyama F, Sawabe M, Arai T, Younes M, et al. Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. Histopathology 2005;47:195-201 https://doi.org/10.1111/j.1365-2559.2005.02181.x
  16. Tsutsumi Y. Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma. Jpn J Clin Oncol 2012;42:375-386 https://doi.org/10.1093/jjco/hys034
  17. Nagao T, Kinoshita T, Hojo T, Tsuda H, Tamura K, Fujiwara Y. The differences in the histological types of breast cancer and the response to neoadjuvant chemotherapy: the relationship between the outcome and the clinicopathological characteristics. Breast 2012;21:289-295 https://doi.org/10.1016/j.breast.2011.12.011
  18. Iizuka M, Enomoto K, Sakurai K. [A case of breast cancer treated with neoadjuvant chemotherapy and segmentectomy]. Gan To Kagaku Ryoho 2012;39:2027-2029
  19. Japaze H, Emina J, Diaz C, Schwam RJ, Gercovich N, Demonty G, et al. 'Pure' invasive apocrine carcinoma of the breast: a new clinicopathological entity? Breast 2005;14:3-10 https://doi.org/10.1016/j.breast.2004.06.003
  20. Tanaka K, Imoto S, Wada N, Sakemura N, Hasebe K. Invasive apocrine carcinoma of the breast: clinicopathologic features of 57 patients. Breast J 2008;14:164-168 https://doi.org/10.1111/j.1524-4741.2007.00548.x
  21. d'Amore ES, Terrier-Lacombe MJ, Travagli JP, Friedman S, Contesso G. Invasive apocrine carcinoma of the breast: a long term follow-up study of 34 cases. Breast Cancer Res Treat 1988;12:37-44 https://doi.org/10.1007/BF01805738

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