Molecules and Cells

  • 제38권12호
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  • Pages.1029-1036
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  • 2015
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development

  • Oh, Se-Yeong (Department of Pediatrics, Emory University School of Medicine) ;
  • Kim, Ju Young (Department of Pediatrics, Emory University School of Medicine) ;
  • Park, Changwon (Department of Pediatrics, Emory University School of Medicine)
  • 투고 : 2015.12.07
  • 심사 : 2015.12.10
  • 발행 : 2015.12.31
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초록

Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.

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참고문헌

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