Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
권호 표지
DOI QR코드

DOI QR Code

The Association of Metabolic Syndrome and Vitamin D in Korean Menopausal Women: Korea National Health and Nutrition Survey, 2010~2012

한국 폐경기 여성에서 대사증후군과 비타민 D의 관련성: 2010~2012 국민건강영양조사에 근거하여

  • Roh, Eun Kyung (Department of Hospital Administration, Dong Kang University) ;
  • Yoon, Hyun (Department of Biomedical Laboratory Science, Hanlyo University)
  • 노은경 (동강대학교 보건행정학과) ;
  • 윤현 (한려대학교 임상병리학과)
  • Received : 2015.10.27
  • Accepted : 2015.11.06
  • Published : 2015.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to assess the association of metabolic syndrome and Vitamin D in Korean adults. The study subjects were Korean menopausal woman (n=4,340) who participated in the Korea National Health and Nutrition Examination Survey 2010~2012. After adjusting for factors such as age, body mass index, total cholesterol, smoking, and regular exercise, the mean 25(OH)D levels ($M{\pm}SE$) decreased with increasing metabolic syndrome score (MSS) (MSS 0, $18.18{\pm}0.29ng/Ml$; MSS 1, $18.09{\pm}0.21ng/mL$; MSS 2, $18.07{\pm}0.19ng/mL$; MSS 3, $18.04{\pm}0.21ng/mL$; MSS ${\geq}4$, $17.27{\pm}0.23ng/mL$), and the mean 25(OH)D level ($M{\pm}SE$) for metabolic syndrome ($17.66{\pm}0.16ng/mL$) decreased in comparison to non-metabolic syndrome ($18.11{\pm}0.14ng/mL$). In conclusion, our results suggest that an increase in metabolic syndrome score or metabolic syndrome are inversely associated with the vitamin D levels.

본 연구는 국가자료인 제 5기 국민건강영양조사 자료(2010~2012)를 이용하여 폐경기 여성(n=4,340)에서 대사증후군과 비타민 D의 관련성을 평가하고자 실시하였다. 연구결과에서 연령, BMI, TC, 흡연습관 및 중등도 신체활동을 보정한 후, 25(OH)D에 대한 평균값($M{\pm}SE$)이 MSS 0은 $18.18{\pm}0.29ng/mL$, MSS 1은 $18.09{\pm}0.21ng/mL$, MSS 2는 $18.07{\pm}0.19ng/mL$, MSS 3은 $18.04{\pm}0.21ng/mL$, MSS ${\geq}4$는 $17.27{\pm}0.23ng/mL$로 MSS가 증가할수록 감소하였고(p=0.041), 비 대사증후군($18.11{\pm}0.14ng/mL$)에 비하여 대사증후군($17.66{\pm}0.16ng/mL$)에서 유의하게 증가하였다(p=0.042). 결론적으로 대사증후군 구성요소의 증가와 대사증후군은 비타민 D의 수준과 역으로 관계가 있다.

Keywords

References

  1. Brandenburg VM, Vervloet MG, Marx N. The role of vitamin D in cardiovascular disease: From present evidence to future perspectives. Atherosclerosis. 2012, 225:253-263. https://doi.org/10.1016/j.atherosclerosis.2012.08.005
  2. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003, 88:2404-2411. https://doi.org/10.1210/jc.2003-030242
  3. Cozzolino M, Stucchi A, Rizzo MA. Vitamin D receptor activation and prevention of arterial ageing. Nutrition, metabolism, and cardiovascular diseases. 2012, 22:547-552. https://doi.org/10.1016/j.numecd.2012.03.010
  4. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002, 287:356-359. https://doi.org/10.1001/jama.287.3.356
  5. Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007, 92:399-404. https://doi.org/10.1210/jc.2006-0513
  6. Guasch A, Bullo M, Rabassa A, Bonada A, Castillo DD, Sabench F, et al. Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study. Cardiovasc Diabetol. 2012, 11:149. https://doi.org/10.1186/1475-2840-11-149
  7. Hollis BW, Horst RL. The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going. J. Steroid. Biochem. Mol Biol. 2007, 103:473-476. https://doi.org/10.1016/j.jsbmb.2006.11.004
  8. Isomaa B, Almgren P, Forsen B, Torsen B, Laht K, Nissen M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001, 24:683-689. https://doi.org/10.2337/diacare.24.4.683
  9. Khader YS, Batieha A, Jaddou H, Batieha Z, El-Khateeb M, Ajlouni K. Relationship between 25-Hydroxyvitamin D and metabolic syndrome among Jordanian adults. Nutr Res Pract. 2011, 5:132-139. https://doi.org/10.4162/nrp.2011.5.2.132
  10. Kim HM, Park J, Ryu SY, Kim J. The effect of menopause on the metabolic syndrome among Korean women: the Korean National Health and Nutrition Examination Survey, 2001. Diabetes Care. 2007, 30:701-706. https://doi.org/10.2337/dc06-1400
  11. Kim YE. The association between vitamin D deficiency and frailty syndrome. J Korean life Insur Med Assoc. 2007, 26:3-12.
  12. Lagunova Z, Porojnicu AC, Vieth R. Serum 25-hydroxyvitamin D is a predictor of serum 1,25-dihydroxyvitamin D in overweight and obese patients. Pediatric diabetes. 2011, 141:112-117.
  13. Lee HJ, Kwon HS, Park YM, Chun HN, Choi YH, Ko SH, et al. Waist circumference as a risk factor for metabolic syndrome in Korean adult evaluation from 5 different criteria of metabolic syndrome. J Korean Diabetes Assoc. 2005, 29:48-56.
  14. Lee KS, Yoon YS, Yoon H. The association of abdominal obesity, obesity and parathyroid hormone in Korean adults (aged${\geq}$50 years): The Korea National Health and Nutrition Survey, 2011. J Korea Acad Industr Coop Soc. 2015, 16:3882-3888. https://doi.org/10.5762/KAIS.2015.16.6.3882
  15. Lee SH, Kim SM, H. S. Park HS. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutr Metab Ccardiovas. 2013, 23:785-791. https://doi.org/10.1016/j.numecd.2012.04.013
  16. Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, et al. Plasma 25-Hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009, 32:1278-1283. https://doi.org/10.2337/dc09-0209
  17. McNeill AM, Rosamond WD, Girman CK, Golden SH, Schmidt ML, East HE, et al. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities Study. Diabetes Care. 2005, 28:385-390. https://doi.org/10.2337/diacare.28.2.385
  18. Meigs JB. Invited commentary: insulin resistance syndrome "syndrome X" multiple metabolic syndrome a syndrome at all factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am J Epidemiol. 2000, 152:908-911. https://doi.org/10.1093/aje/152.10.908
  19. Misr M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008, 122:398-417. https://doi.org/10.1542/peds.2007-1894
  20. Moon HK, Kim YD, Yang DG, Kim SG, Cha KS, Kim MH, et al. Age and Gender Distribution of Patients with Acute Myocardial Infarction Admitted to University Hospitals during the Period of 1990-1999. Korean Circ J. 2003, 33:92-96. https://doi.org/10.4070/kcj.2003.33.2.92
  21. Muscogiuri G, Sorice GP, Ajjan R. Can vitamin D deficiency cause diabetes and cardiovascular diseases: Present evidence and future perspectives. Nutr Metab Ccardiovas. 2012, 22:81-87. https://doi.org/10.1016/j.numecd.2011.11.001
  22. NCEP; NHLBI; NIH. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001, 285:2486-2497. https://doi.org/10.1001/jama.285.19.2486
  23. Park HY, Lim YH, Kim JH, Bae SH, Oh SY, Hong YC. Association of serum 25-hydroxyvitamin D levels with markers metabolic syndrome in the elderly: A repeated measure analysis. J Korean Med Sci. 2012;27:653-660. https://doi.org/10.3346/jkms.2012.27.6.653
  24. Park SM, Lee BK. Vitamin D deficiency is an independent risk factor for cardiovascular disease in Koreans aged years: results from the Korean National Health and Nutrition Examination Survey. Nutr Res Pract. 2012, 6:162-168. https://doi.org/10.4162/nrp.2012.6.2.162
  25. Prentice A, Goldberg GR, Schoenmakers I. Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr. 2008, 88:500-506. https://doi.org/10.1093/ajcn/88.2.500S
  26. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1998, 37:1598-1607.
  27. Shin HA, Om AS. The correlation between dietary intake of calcium and vitamin D and osteoporosis, hypertension and diabetes mellitus. Korean Dairy Techno. 2009, 27:17-23.
  28. Shin KA. Prevalence of metabolic syndrome according to menopausal status: The 5th Korea National Health & Nutrition Examination Survey. Korean J Clin Lab Sci. 2014, 46:85-90. https://doi.org/10.15324/kjcls.2014.46.3.85
  29. WHO; IASO; IOTF. The Asia-Pacific perspective: Redefinding obesity and its treatment. 2000, World Health Organization, Geneva.
  30. Yoon H, Kim GS, Kim SG, Moon AE. The relationship between metabolic syndrome and increase of metabolic syndrome score and serum vitamin D levels in Korean adults: 2012 Korean National Health and Nutrition Examination Survey. J Clin Biochem Nutr. 2015, 57:82-87. https://doi.org/10.3164/jcbn.15-31

Cited by

  1. 한국 여성의 혈중 비타민 D 결핍에 영향을 미치는 요인: 제5기 국민건강영양조사 자료 활용 vol.15, pp.10, 2015, https://doi.org/10.14400/jdc.2017.15.10.357
  2. A Fusion Study on the Relationship between Lifestyle and Vitamin D Deficiency in Korean Adults vol.10, pp.12, 2015, https://doi.org/10.15207/jkcs.2019.10.12.159