대한수의학회지 (Korean Journal of Veterinary Research)

  • 제55권4호
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  • Pages.263-266
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  • 2015
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Drug-induced blood cell dyscrasia associated with phenobarbital administration in a dog

  • Jung, Han-Byeol (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 투고 : 2015.10.31
  • 심사 : 2015.12.15
  • 발행 : 2015.12.31
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초록

A 13-year-old, spayed, female Chihuahua dog was referred for evaluation of fever, lethargy, and dyspnea. Hematologic evaluation revealed severe neutropenia, thrombocytopenia, and mild anemia. The dog had been undergoing phenobarbital therapy for the past 7 weeks because of generalized seizures due to meningoencephalomyelitis of unknown etiology. After ruling out other possible causes of cytopenias, a tentative diagnosis was made of drug-induced blood cell dyscrasia. The neutropenia and thrombocytopenia resolved after discontinuation of phenobarbital (8 days and 15 days after discontinuation, respectively). This is the first case report in Korea to demonstrate blood dyscrasia associated with idiosyncratic adverse effects of phenobarbital.

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참고문헌

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피인용 문헌

  1. Bone marrow, blood, and clinical findings in dogs treated with phenobarbital vol.50, pp.1, 2015, https://doi.org/10.1111/vcp.13013