Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Factors associated with Occurrence of Aspiration Pneumonia in the Patient with Sedative-hypnotics Acute Overdose

수면진정제 중독 환자에서 흡인성 폐렴 발생의 예측 인자 분석

  • Kang, Min Jin (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lim, Jee Yong (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Oh, Sang Hoon (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Han Joon (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Young-Min (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea)
  • 강민진 (가톨릭대학교 의과대학 응급의학교실) ;
  • 임지용 (가톨릭대학교 의과대학 응급의학교실) ;
  • 오상훈 (가톨릭대학교 의과대학 응급의학교실) ;
  • 김한준 (가톨릭대학교 의과대학 응급의학교실) ;
  • 김영민 (가톨릭대학교 의과대학 응급의학교실)
  • Received : 2015.09.24
  • Accepted : 2015.12.22
  • Published : 2015.12.31
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Abstract

Purpose: Drug overdose is easily found in the emergency department (ED). Sedative-hypnotics overdose causes the aspiration pneumonia in patients with decreased mental status. The purpose of this study was to investigate the risk factors of aspiration pneumonia in patients poisoned with sedative-hypnotics. Methods: One hundred seventy eight patients who were poisoned with sedative-hypnotics and who visited ED between 2009 and 2015 were included. This study was conducted retrospectively, with collection of data by review of medical records. We collected the data concerning the characteristics of patients and classified them into two groups based on the development of aspiration pneumonia. Logistic regression analysis was performed to investigate the factors for the development of aspiration pneumonia. Results: Thirty five patients had an aspiration pneumonia during their hospital stay in 178 patients. The age, amount of ingestion, Glasgow Coma Scale (GCS) score at admission, a history of hypertension and diabetes mellitus, and the hypotension at admission were significantly different between two groups in univariate analysis. The age, amount of ingestion and GCS score at admission were associated with the development of aspiration pneumonia in the multivariate logistic regression analysis (OR 1.028 (95%CI, 1.002-1.056, p=0.037), 1.026 (95%CI, 1.004-1.043, p=0.001), 0.737 (95%CI, 0.683-0.915, p=0.002)). All patients with aspiration pneumonia were discharged without a sequelae. Conclusion: The development of aspiration pneumonia in the patients of sedative-hypnotics overdose is associated with old age, amount of drug ingestion, and GCS score at admission.

Keywords

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