The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells

  • Song, Yu Seok (Department of Biochemistry, Chung-Ang University College of Medicine) ;
  • Balcos, Marie Carmel (Department of Biochemistry, Chung-Ang University College of Medicine) ;
  • Yun, Hye-Young (Department of Biochemistry, Chung-Ang University College of Medicine) ;
  • Baek, Kwang Jin (Department of Biochemistry, Chung-Ang University College of Medicine) ;
  • Kwon, Nyoun Soo (Department of Biochemistry, Chung-Ang University College of Medicine) ;
  • Kim, Myo-Kyoung (Thomas J. Long School of Pharmacy, University of the Pacific) ;
  • Kim, Dong-Seok (Department of Biochemistry, Chung-Ang University College of Medicine)
  • Received : 2014.08.30
  • Accepted : 2014.12.01
  • Published : 2015.01.30
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Abstract

Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation.

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References

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