Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Inhibitory Effect of Penthorun chinense Extract on Allergic Responses in vitro and in vivo

낙지다리 식물 추출물의 알레르기 억제효과

  • Jo, So young (College of Pharmacy, Duksung Women's University) ;
  • Kim, Young Mi (College of Pharmacy, Duksung Women's University)
  • 조소영 (덕성여자대학교 약학대학) ;
  • 김영미 (덕성여자대학교 약학대학)
  • Received : 2015.11.26
  • Accepted : 2015.12.10
  • Published : 2015.12.30
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Abstract

Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.

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