Ocean and Polar Research

  • 제37권4호
  • /
  • Pages.279-285
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  • 2015
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  • 1598-141X(pISSN)
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  • 2234-7313(eISSN)
한국해양과학기술원 (Korea Institute of Ocean Science & Technology)
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꽈배기모자반 추출물이 3T3-L1 지방세포 분화에 미치는 영향

Inhibitory Effect of Crude Extracts from a Brown Alga Sargassum siliquanstrum on 3T3-L1 Adipocyte Differentiation

  • 공창숙 (신라대학교 의생명과학대학 식품영양학과) ;
  • 이정임 (한국해양대학교 해양과학기술대학 해양생명과학부) ;
  • 권명숙 (신라대학교 의생명과학대학 식품영양학과) ;
  • 서영완 (한국해양대학교 해양과학기술대학 해양생명과학부)
  • Kong, Chang-Suk (Department of Food and Nutrition, College of Medical and Life Sciences, Silla University) ;
  • Lee, Jung Im (Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University) ;
  • Kwon, Myeong Sook (Department of Food and Nutrition, College of Medical and Life Sciences, Silla University) ;
  • Seo, Youngwan (Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University)
  • 투고 : 2015.10.22
  • 심사 : 2015.11.28
  • 발행 : 2015.12.30
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초록

In this study, the potential capacity of the crude extract and its solvent fractions from S. siliquanstrum against adipocyte differentiation were evaluated in 3T3-L1 adipocytes. The anti-adipogenic effect of S. siliquanstrum was evidenced by the fact that its crude extract decreases the lipid accumulation of differentiating cells and the expression levels of crucial adipogenesis markers, peroxisome proliferator-activated receptor $(PPAR){\gamma}$ and CCAAT/enhancer-binding protein $(C/EBP){\alpha}$. All solvent fractions except the water fraction showed an observable decrease in lipid accumulation and $PPAR{\gamma}$ and $C/EBP{\alpha}$ expressions. In conclusion, these results suggest that S. siliquanstrum possesses obesity inhibiting components, which may possibly be used as a valuable anti-obesity agent for reducing the risk of obesity.

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참고문헌

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피인용 문헌

  1. before solvent extraction of antioxidant and antiobesity compounds pp.02682575, 2018, https://doi.org/10.1002/jctb.5771