A Case of Primary Small Cell Carcinoma of the Parotid Gland

이하선에 발생한 원발성 소세포암 1예

  • Ko, Young-Bum (Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine) ;
  • Park, Gi Cheol (Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine)
  • 고영범 (성균관대학교 삼성창원병원 이비인후과학교실) ;
  • 박기철 (성균관대학교 삼성창원병원 이비인후과학교실)
  • Received : 2015.06.25
  • Accepted : 2015.09.18
  • Published : 2015.11.30

Abstract

Small cell carcinoma is mainly found in the lungs and extrapulmonary origins of small cell carcinoma in GI tract, head and neck, genitourinary system consists only 4% of the tumor. Thus, small cell carcinoma of the parotid gland is an extremely rare disease. Extrapulmonary small cell carcinoma is characterized by an aggressive clinical course with early metastasis. We report a case of small cell carcinoma of parotid gland in a 82-year-old woman with painless neck mass, who was managed with radiation therapy after surgery and review of relevant literatures.

Keywords

References

  1. Levenson RM, Ihde DC, DC, Matthews MJ. Small cell carcinoma presenting as an extrapulmonary neoplasm: Sites of origin and responses to chemotherapy. JNCI. 1981;67:607-612.
  2. Ibrahim NB, Briggs JC, Corbishley CM. Extrapulmonary oat cell carcinoma. Cancer. 1984;54:1645-1661. https://doi.org/10.1002/1097-0142(19841015)54:8<1645::AID-CNCR2820540828>3.0.CO;2-Q
  3. Olofsson J. van Nostrand AW. Anaplastic small cell carcinoma of larynx: case report. Ann Otol Rhinol Laryngol. 1972;81:284-287. https://doi.org/10.1177/000348947208100218
  4. HW Chang, HW Do, DW Shin, WS Kim. Primary small cell carcinoma of the parotid gland. Korean J Otolaryngol. 2004;47:282-285.
  5. Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer. 1997;79:1729-1736. https://doi.org/10.1002/(SICI)1097-0142(19970501)79:9<1729::AID-CNCR14>3.0.CO;2-#
  6. Duguid JB, Kennedy AM, Oat-cell tumors of mediastinal glands. J Pathol Bacteriol. 1930;33:93-99. https://doi.org/10.1002/path.1700330109
  7. Recant L, Lacy P. Cushing's syndrome associated with a parotid gland tumor. Am J Med. 1963;34:394-406. https://doi.org/10.1016/0002-9343(63)90126-8
  8. Pearse AG. The APUD cell concept and its implications in pathology. Pathol Annu. 1974;9:27-41.
  9. Jaiswal VR, Hoang MP. Primary combined squamous and small cell carcinoma of the larynx: a case report and review of the literature: Arch pathoi Lab Med. 2004;128:1279-1282.
  10. Remick SC, Hafez GR, Carbone PP. Extrapulmonary small-cell carcinoma. A review of literature with emphasis on therapy and outcome. Medicine (Baltimore). 1987;66:457-471. https://doi.org/10.1097/00005792-198711000-00004
  11. Ellis GL, Auclair PL. Atlas of Tumor Pathology 3rd series, fascicle 17: Tumors of the Salivary Glands. Washington, DC: Armed Forces Institute of Pathology; 1996. p.297-306.
  12. Witt R. Primary small cell carcinoma of the parotid gland. Otolaryngol Head Neck Surg. 1996;114:826-829. https://doi.org/10.1016/S0194-5998(96)70111-0
  13. Ferlito A, Barnes L, Rinaldo A, Gnepp D, Milory CM. A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol. 1998;112(9):827-834. https://doi.org/10.1017/S0022215100141830
  14. Yuan ZY, Guan ZZ, Zhou Zm, Xia Y, Huanf WZ, Yang XL. Extrapulmonary small cell carcinoma in 52 patients. Chin J Cancer. 2006;25:1131-1133.
  15. Gnepp DR, Corio RL, Brannon RB. Small cell carcinoma of the major salivary glands. Cancer. 1986;58:705-714. https://doi.org/10.1002/1097-0142(19860801)58:3<705::AID-CNCR2820580318>3.0.CO;2-T