Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Postoperative Serum CEA Level is a More Significant Prognostic Factor than Post/Preoperative Serum CEA Ratio in Non-small Cell Cancer Patients

  • Tomita, Masaki (Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki) ;
  • Ayabe, Takanori (Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki) ;
  • Chosa, Eiichi (Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki) ;
  • Nakamura, Kunihide (Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki)
  • Published : 2015.12.03
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Abstract

Background: In non-small cell lung cancer (NSCLC) patients with preoperative high serum carcinoembryonic antigen (CEA) level, patients with a persistently high serum CEA level after surgery have been reported to have a poor prognosis. In addition, in other cancers, the post/preoperative serum CEA ratio has been reported as a useful parameter. Materials and Methods: We enrolled 123 NSCLC patients with preoperative high CEA levels (${\geq}5ng/mL$) who underwent curative surgery between 2004 and 2011. Prognostic significance of postoperative serum CEA level and the CEA ratio was examined. Results: The 5-year survival of patients with persistently high serum CEA level after surgery was poor. On the other hand, patients with normal postoperative serum CEA levels had significant favorable prognosis. The patients with CEA ratio>1 had poor prognosis, however the number was only 7 (5.7%). The 5-year survival rates of patients with other subgroup based on the CEA ratio ($0.5{\geq}CEA$ ratio and $0.5{\leq}CEA$ $ratio{\leq}1$) was similar. Multivariate analysis revealed prognostic significance for the postoperative serum CEA level but not the CEA ratio. Conclusions: For NSCLC patients with preoperative high serum CEA level, their postoperative serum CEA levels is a more significant prognostic factor than the post/preoperative serum CEA ratio.

Keywords

References

  1. Grunnet M, Sorensen JB (2012). Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer, 76, 138-43. https://doi.org/10.1016/j.lungcan.2011.11.012
  2. Hotta T, Takifuji K, Uchiyama K, et al (2006). Potential predictors of survival after surgery for colorectal cancer patients with synchronous unresectable liver metastases. Oncology Reports, 16, 1369-74.
  3. Hotta T, Takifuji K, Yokoyama S, et al (2014). Impact of the post/preoperative serum CEA ratio on the survival of patients with rectal cancer. Surgery Today, 44, 2106-15. https://doi.org/10.1007/s00595-014-0852-1
  4. Kim CW, Yu CS, Yang SS, et al (2011). Clinical significance of pre- to post-chemoradiotherapy s-CEA reduction ratio in rectal cancer patients treated with preoperative chemoradiotherapy and curative resection. Annals of Surgical Oncology, 18, 3271-7. https://doi.org/10.1245/s10434-011-1740-1
  5. Nonaka M, Kataoka D, Yamamoto S, et al (2004). Pre- and postoperative serum carcinoembryonic antigen in primary lung adenocarcinoma. Annals of Thoracis and Cardiovascular Surgery, 10, 281-4.
  6. Okada M, Nishio W, Sakamoto T, et al (2004). Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. The Annals of Thoracic Surgery, 78, 216-21. https://doi.org/10.1016/j.athoracsur.2004.02.009
  7. Sawabata N, Ohta M, Takeda S, et al (2002). Serum carcinoembryonic antigen level in surgically resected clinical stage I patients with non-small cell lung cancer. The Annals of Thoracic Surgery, 74, 174-9. https://doi.org/10.1016/S0003-4975(02)03662-7
  8. Sawabata N, Maeda H, Yokota S, et al (2004). Postoperative serum carcinoembryonic antigen levels in patients with pathologic stage IA nonsmall cell lung carcinoma: subnormal levels as an indicator of favorable prognosis. Cancer, 101, 803-9. https://doi.org/10.1002/cncr.20421
  9. Takamochi K, Nagai K, Suzuki K, et al (2000). Clinical predictors of N2 disease in non-small cell lung cancer. Chest, 117, 1577-82. https://doi.org/10.1378/chest.117.6.1577
  10. Tomita M, Matsuzaki Y, Edagawa M, et al (2004). Prognostic significance of preoperative serum carcinoembryonic antigen level in lung adenocarcinoma but not squamous cell carcinoma. Annals of Thoracis and Cardiovascular Surgery, 10, 76-80.
  11. Tomita M, Matsuzaki Y, Shimizu T, et al (2005). Prognostic determinants for lung cancer patients with preoperative high serum carcinoembryonic antigen levels. Thoracic and Cardiovascular Surgeon, 53, 300-4. https://doi.org/10.1055/s-2005-865671
  12. Wang CY, Huang MS, Huang MH, et al (2010). Persistently high serum carcinoembryonic antigen levels after surgery indicate poor prognosis in patients with stage I non-small-cell lung cancer. Journal of Surgical Research, 163, 45-50. https://doi.org/10.1016/j.jss.2010.04.039
  13. Yamazaki K, Yoshino I, Yohena T, et al (2007). Clinically predictive factors of pathologic upstaging in patients with peripherally located clinical stage IA non-small cell lung cancer. Lung Cancer, 55, 365-9. https://doi.org/10.1016/j.lungcan.2006.10.004

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