Bulletin of the Korean Chemical Society

  • 제35권12호
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  • Pages.3632-3636
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  • 2014
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides

  • Dinh, Thuy T.T. (College of Pharmacy, Dongguk University) ;
  • Kim, Do-Hee (College of Pharmacy, Seoul National University) ;
  • Lee, Bong-Jin (College of Pharmacy, Seoul National University) ;
  • Kim, Young-Woo (College of Pharmacy, Dongguk University)
  • 투고 : 2014.08.28
  • 심사 : 2014.09.19
  • 발행 : 2014.12.20
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초록

In this study we designed and synthesized several heptapeptides that are enforced to form an amphipathic helix using all-hydrocarbon stapling system and evaluated their antimicrobial and hemolytic activities. The antimicrobial activity showed clear structure-activity relationships, confirming the importance of helicity and amphipathicity. Some stapled heptapeptides displayed a moderate antimicrobial activity along with a low hemolytic activity. To our best knowledge, although not highly potent, these stapled peptides represent the shortest helical amphipathic antimicrobial peptides reported to date. The preliminary data obtained in this work would serve as a good starting point for further developing short analogs of amphipathic helical antimicrobial peptides.

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피인용 문헌

  1. -Capping Effects of Stapled Heptapeptides on Antimicrobial and Hemolytic Activities vol.36, pp.10, 2015, https://doi.org/10.1002/bkcs.10483
  2. Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers vol.37, pp.8, 2016, https://doi.org/10.1002/bkcs.10839
  3. Antimicrobial activity and stability of stapled helices of polybia-MP1 vol.40, pp.12, 2017, https://doi.org/10.1007/s12272-017-0963-5
  4. Hydrocarbon Stapled Antimicrobial Peptides vol.37, pp.1, 2018, https://doi.org/10.1007/s10930-018-9755-0
  5. Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides pp.1976-3786, 2018, https://doi.org/10.1007/s12272-018-1084-5
  6. All-Hydrocarbon Staples and Their Effect over Peptide Conformation under Different Force Fields vol.58, pp.9, 2014, https://doi.org/10.1021/acs.jcim.8b00404
  7. De Novo Hydrocarbon-Stapling Design of Single-Turn α-Helical Antimicrobial Peptides vol.26, pp.4, 2020, https://doi.org/10.1007/s10989-019-09964-7
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