DOI QR코드

DOI QR Code

Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities

  • Li, Chungang (Shanghai Institute of Pharmaceutical Industry, State Institute of Pharmaceutical Industry) ;
  • Sun, Yiping (Shanghai Shyndec Pharmaceutical Co., Ltd) ;
  • Wang, Guoping (Shanghai Institute of Pharmaceutical Industry, State Institute of Pharmaceutical Industry) ;
  • Tan, Xiangduan (College of pharmacy, Guilin Medical University)
  • 투고 : 2014.06.27
  • 심사 : 2014.08.11
  • 발행 : 2014.12.20

초록

In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.

키워드

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