Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Association between Low Density Lipoprotein Cholesterol and Pulmonary Function among Premenopausal women in their 40s: a Retrospective Cohort study

40대 폐경 전 여성에서 저밀도 지단백 콜레스테롤과 폐 기능의 연관성: 후향적 코호트 연구

  • Ko, Hae-Jin (Department of Family Medicine, Kyungpook National Univertisy Hospital, Kyungpook National Univertisy School of Medicine) ;
  • Youn, Chang-Ho (Department of Family Medicine, Kyungpook National Univertisy Hospital, Kyungpook National Univertisy School of Medicine) ;
  • Kim, Seong-Hyun (Division of Applied Entomology, National Academy of Agricultural Science, Rural Development Administration)
  • 고혜진 (경북대학교 의학전문대학원 경북대학교병원 가정의학과) ;
  • 윤창호 (경북대학교 의학전문대학원 경북대학교병원 가정의학과) ;
  • 김성현 (농촌진흥청 국립농업과학원 농업생물부 곤충산업과)
  • Received : 2014.07.14
  • Accepted : 2014.11.06
  • Published : 2014.11.30
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Abstract

The aim of this study was to identify the correlation between low density lipoprotein (LDL) cholesterol and the pulmonary function. This study enrolled premenopausal women in their aged 40s, who visited the health promotion center of a general hospital more than two times. A total of 384 subjects were classified into four groups based on their LDL-cholesterol levels; A, LDL(mg/dL)<100 at both initial and follow-up; B, LDL<100 at initial but ${\geq}100$ at follow-up; C, $LDL{\geq}100$ at initial but <100 on follow-up; and D, $LDL{\geq}100$ at both the initial and follow-up test. The result showed no significant differences in the pulmonary function between the four groups. Multiple linear regression analysis, which was adjusted for age, body mass index, smoking, exercise, and follow-up duration, showed a significant negative relationship between the changes in the LDL and the changes in the $FEV_1/FVC$ (${\beta}=-0.109$, S.E.=0.029, P<0.001), but not in the $FEV_1$ and FVC. In conclusion, there was a significant but weak relationship between the LDL and pulmonary function. Further larger studies will be needed.

저밀도 지단백과 폐 기능과의 상관관계를 살펴보고자 2001년 1월부터 2011년 12월까지 일개지역 대학병원의 건강증진 센터를 방문하여 2회 이상 검사를 시행한 40-49세의 폐경 전 여성을 대상으로 연구하였다. 최종 384명의 대상자를 LDL(mg/dL)을 기준으로 초기와 추적검사에서 모두 100미만인 A군, 초기 검사에서는 100미만이었으나 추적검사에서 100이상인 B군, 초기 검사에서는 100이상이었으나 추적검사에서 100미만인 C군, 초기와 추적검사 모두에서 100이상인 D군으로 나누었다. 네 군간 폐 기능 검사는 초기, 추적검사 모두 통계적으로 유의한 차이를 보이지 않았다. 나이, 체질량지수, 흡연, 운동, 추적기간을 보정하여 LDL 변화량과 폐 기능 변화량에 대해 다중회귀분석을 시행한 결과 $FEV_1/FVC$/FVC에 대해 유의한 음의 상관관계가 나타났고(${\beta}=-0.109$, S.E.=0.029, P<0.001), 그 외에는 유의한 결과를 보이지 않았다. 결론적으로 LDL과 폐기능 변화량은 음의 상관관계가 있으며, 향후 대규모의 연구가 필요하다.

Keywords

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