Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Genetic Variation in PSCA is Associated with Bladder Cancer Susceptibility in a Korean Population

  • Lee, Jun-Ho (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Song, Hye-Rim (Department of Laboratory Medicine, Chonnam National University Hwasun Hospital) ;
  • Kim, Hee Nam (Center for Creative Biomedical Scientists, Chonnam National University) ;
  • Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Yun, Yong-Woon (Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital) ;
  • Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Jung, Seung-Il (Department of Urology, Chonnam National University Medical School) ;
  • Kwon, Dong Deuk (Department of Urology, Chonnam National University Medical School) ;
  • Kim, Soo Hyun (Department of Laboratory Medicine, Chonnam National University Medical School) ;
  • Choi, Yoo-Duk (Department of Pathology, Chonnam National University Medical School) ;
  • Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School)
  • Published : 2014.11.06
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Genetic factors play important roles in the pathogenesis of human cancer. A recent genome wide association study (GWAS) identified an association between the rs2294008 polymorphism of the prostate stem cell antigen (PSCA) gene and bladder cancer risk in Caucasians. The aim of this study was to determine whether the rs2294008 polymorphism is similarly associated with bladder cancer susceptibility in a Korean population. Materials and Methods: We conducted a case-control study of 411 bladder cancer patients and 1,700 controls. Results: The frequencies of the CC, CT, and TT genotypes of the rs2294008 polymorphism were 16.9, 54.0, and 28.8% in bladder cancer patients and 24.4, 48.1, and 27.5% in controls, respectively. We found that the combined CT/TT genotypes were associated with a significantly increased risk of bladder cancer (OR CT/TT =1.58, 95% CI= 1.15-2.17), compared with the CC genotype. Smoking habits, tumor grade and tumor stage did not modify the association between rs2294008 and the risk of bladder cancer. Conclusions: Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.

Keywords

References

  1. Dudek AM, Grotenhuis AJ, Vermeulen SH, et al (2013). Urinary bladder cancer susceptibility markers. what do we know about functional mechanisms? Int J Mol Sci, 14, 12346-66. https://doi.org/10.3390/ijms140612346
  2. Fu YP, Kohaar I, Rothman N, et al (2012). Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk. Proc Natl Acad Sci USA, 109, 4974-9. https://doi.org/10.1073/pnas.1202189109
  3. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  4. Kiemeney LA, Sulem P, Besenbacher S, et al (2010). A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet, 42, 415-9. https://doi.org/10.1038/ng.558
  5. Kiemeney LA, Thorlacius S, Sulem P, et al (2008). Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet, 40, 1307-12. https://doi.org/10.1038/ng.229
  6. Kiriluk KJ, Prasad SM, Patel AR, et al (2012). Bladder cancer risk from occupational and environmental exposures. Urol Oncol, 30, 199-211. https://doi.org/10.1016/j.urolonc.2011.10.010
  7. Ma Z, Hu Q, Chen Z, et al (2013). Systematic evaluation of bladder cancer risk-associated single-nucleotide polymorphisms in a chinese population. Mol Carcinog, 52, 916-21. https://doi.org/10.1002/mc.21932
  8. Rafnar T, Vermeulen SH, Sulem P, et al (2011). European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. Hum Mol Genet, 20, 4268-81. https://doi.org/10.1093/hmg/ddr303
  9. Rothman N, Garcia-Closas M, Chatterjee N, et al (2010). A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet, 42, 978-84. https://doi.org/10.1038/ng.687
  10. Saeki N, Gu J, Yoshida T, et al (2010). Prostate stem cell antigen: a Jekyll and Hyde molecule? Clin Cancer Res, 16, 3533-8. https://doi.org/10.1158/1078-0432.CCR-09-3169
  11. Sakamoto H, Yoshimura K, Saeki N, et al (2008). Genetic variation in PSCA is associated with susceptibility to diffusetype gastric cancer. Nat Genet, 40, 730-40. https://doi.org/10.1038/ng.152
  12. Song HR, Kim HN, Piao JM, et al (2011). Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population. Mol Carcinog, 50, 871-5. https://doi.org/10.1002/mc.20796
  13. The Korea Central Cancer Registry NCC (2012). Annual report of cancer statistics in Korea in 2010. Ministry of Health and Welfare.
  14. Volanis D, Kadiyska T, Galanis A, et al (2010). Environmental factors and genetic susceptibility promote urinary bladder cancer. Toxicol Lett, 193, 131-7. https://doi.org/10.1016/j.toxlet.2009.12.018
  15. Wallerand H, Bakkar AA, de Medina SG, et al (2005). Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens. Carcinogenesis, 26, 177-84.
  16. Wang P, Ye D, Guo J, et al (2014). Genetic score of multiple riskassociated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. Genes Chromosomes Cancer, 53, 98-105. https://doi.org/10.1002/gcc.22121
  17. Wang S, Tang J, Wang M, et al (2010). Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population. Carcinogenesis, 31, 621-4. https://doi.org/10.1093/carcin/bgp323
  18. Wang T, Zhang L, Li H, et al (2012). Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev, 21, 843-50. https://doi.org/10.1158/1055-9965.EPI-11-1176
  19. Wu X, Ye Y, Kiemeney LA, et al (2009). Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet, 41, 991-5. https://doi.org/10.1038/ng.421
  20. Wu XR (2005). Urothelial tumorigenesis: a tale of divergent pathways. Nat Rev Cancer, 5, 713-25. https://doi.org/10.1038/nrc1697
  21. Zeegers MP, Tan FE, Dorant E, et al (2000). The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer, 89, 630-9. https://doi.org/10.1002/1097-0142(20000801)89:3<630::AID-CNCR19>3.0.CO;2-Q

Cited by

  1. Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population vol.7, pp.2, 2016, https://doi.org/10.3390/genes7020009
  2. PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism vol.40, pp.5, 2018, https://doi.org/10.1007/s13258-018-0653-9