Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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hARIP2 is a Putative Growth-promoting Factor Involved in Human Colon Tumorigenesis

  • Gao, Rui-Feng (Changchun University of Science and Technology) ;
  • Li, Zhan-Dong (College of Biology and Food Engineering, Jilin Teachers Institute of Engineering and Technology) ;
  • Jiang, Jing (Changchun University of Science and Technology) ;
  • Yang, Li-Hua (Changchun University of Science and Technology) ;
  • Zhu, Ke-Tong (College of Biology and Food Engineering, Jilin Teachers Institute of Engineering and Technology) ;
  • Lin, Rui-Xin (The Second Hospital of Jilin University) ;
  • Li, Hao (College of Biology and Food Engineering, Jilin Teachers Institute of Engineering and Technology) ;
  • Zhao, Quan (Changchun University of Science and Technology) ;
  • Zhang, Nai-Sheng (College of Veterinary Medicine, Jilin University)
  • Published : 2014.11.06
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Abstract

Activin is a multifunctional growth and differentiation factor of the growth factor-beta (TGF-${\beta}$) superfamily, which inhibits the proliferation of colon cancer cells. It induces phosphorylation of intracellular signaling molecules (Smads) by interacting with its type I and type II receptors. Previous studies showed that human activin receptor-interacting protein 2 (hARIP2) can reduce activin signaling by interacting with activin type II receptors; however, the activity of hARIP2 in colon cancer has yet to be detailed. In vitro, overexpression of hARIP2 reduced activin-induced transcriptional activity and enhanced cell proliferation and colony formation in human colon cancer HCT8 cells and SW620 cells. Also, hARIP2 promoted colon cancer cell apoptosis, suggesting that a vital role in the initial stage of colon carcinogenesis. In vivo, immunohistochemistry revealed that hARIP2 was expressed more frequently and much more intensely in malignant colon tissues than in controls. These results indicate that hARIP2 is involved in human colon tumorigenesis and could be a predictive maker for colon carcinoma aggressiveness.

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References

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