Correlations among Respiratory Function, UPDRS and Senior Fitness in Parkinson's Disease Patients

파킨슨병환자의 호흡기능, UPDRS 및 Senior Fitness의 관련성

  • 강동연 (동주대학교 물리치료과) ;
  • 천상명 (동아대학교병원 파킨슨병센터) ;
  • 성혜련 (동아대학교병원 파킨슨병센터) ;
  • 이경순 (동주대학교 물리치료과) ;
  • 김경 (대구대학교 물리치료과)
  • Received : 2014.03.21
  • Accepted : 2014.04.09
  • Published : 2014.04.25

Abstract

Purpose: The purpose of this study was to examine correlations among UPDRS, respiratory function, and senior fitness and to investigate the effects of restrictive respiratory function on these factors in Parkinson's disease patients. Methods: Subjects (n=25, Hoehn & Yahr (H&Y) stage: 2-3, $69.3{\pm}5.9$ yrs) from D Hospital Parkinson's Disease Center at Busan metropolitan area in the Republic of Korea volunteered for this study. They performed the pulmonary function test, UPDRS, and the senior fitness test. SPSS 18.0 was used for analysis of data, and the collected data were analyzed using Pearson's correlation coefficient (n=25). In addition, Independent t-test was used for determination of differences between two groups (between the normal pulmonary function group (n=10) and the restrictive pulmonary function group (n=10)). Results: Forced vital capacity (FVC (L)) showed significant negative correlation (r=-0.44, p<0.05) with H&Y stage in Parkinson's disease patients, and chair stand showed significant negative correlations (r=0.41, 0.43, 0.42, p<0.05) with FVC (L), FVC (%), and FEV1 (L). FVC (%) showed significant positive correlations (r=0.44, r=0.44, p<0.05) with right and left back scratch. In addition, the restrictive respiratory function group showed significantly lower FVC (%) (p<0.01) and was significantly slower (p<0.05) in the 8-foot up-and-go test than the normal respiratory function group. Conclusion: In conclusion, these results suggest that restrictive respiratory function in PD was related to H&Y stage. In addition, agility of PD patients was lower in the restrictive respiratory function group than in the normal function group.

Keywords

References

  1. Kwon YH. Influence of time of day on respiratory function in normal healthy subjects. J Korean Soc Phys Ther. 2013;25(6):374-78.
  2. Lalley PM. The aging respiratory system Pulmonary strucuture, function and neural control. Respir Physiol Neurobiol. 2013;187(3):199-210. https://doi.org/10.1016/j.resp.2013.03.012
  3. Guedes LU, Rodrigues JM, Fernandes AA. Respiratory changes in Parkinson's disease may be unrelated to dopaminergic dysfunction. Arq Neuropsiquiatr. 2012;70(11):841-51.
  4. Inzelberg R, Peleg N, Nispeanu P et al. Inspiratory Muscle Training and the Perception of Dyspnea in Parkinson's Disease. Can J Neurol Sciences. 2005;32(2):213-17. https://doi.org/10.1017/S0317167100003991
  5. Mehanna R, Jankovic J. Respiratory problems in neurologic movement disorders. Parkinsonisom relat Disord. 2010;16(10):628-38. https://doi.org/10.1016/j.parkreldis.2010.07.004
  6. Monteiro L, Souza-Machado A, Pinho P. Swallowing impairment and pulmonary dysfunction in Parkinson's disease: The silent threats. J Neurol Sci. 2014: 1-4.
  7. Polatil M, Akyol A, Cildag O et al. Pulmonary function tests in Parkinson's disease. Eur J Neurol. 2001;8(4):341-45. https://doi.org/10.1046/j.1468-1331.2001.00253.x
  8. Seccombe LM, Giddings HL, Rogers PG et al. Abnormal ventilator control in Parkinson's disease-Further evidence for non-motor dysfunction. Respi physiol Neorobiol. 2011;179(2-3):300-04. https://doi.org/10.1016/j.resp.2011.09.012
  9. Monteiro L, Souza-Machado A, Valderramas S. The Effect of Levodopa on Pulmonary Function in Parkinson's Disease: A Systematic Review and Meta-Analysis. Clin Ther. 2012;35(5):1049-1055.
  10. Pitts T, Troche M, Mann G et al. Using Voluntary Cough to Detect Penetration and Aspiration During Oropharyngeal Swallowing in Patients With Parkinson Disease. Chest. 2010;138(6):1426-31. https://doi.org/10.1378/chest.10-0342
  11. Salhi B, Behaegel M, Troosters T et al. Effects of Pulmonary Rehabilitation in Patients with Restrictive Lung Diseases. Chest. 2010;137(2):273-79. https://doi.org/10.1378/chest.09-0241
  12. Scarlata S, Pedone C, Fimognari FL. Restrictive pulmonary dysfunction at spirometry and mortality in the elderly. Respir Med. 2008;102(9):1349-54. https://doi.org/10.1016/j.rmed.2008.02.021
  13. Barbirato D, Carvalho A, de Araujo NB et al. Muscle Strength and Executive Function as Complementary Parameters for Assessment of Impairment in Parkinson's Disease. Arq Neuropsiquiatr. 2013;71(12):948-54. https://doi.org/10.1590/0004-282X20130175
  14. Kim MY, Kim CW, Lim BO. Effects of Hoehn-Yahr Scale on the Gait with Parkinson's Patients. Kor J Physi Edu. 2013;52(4):545-52.
  15. Goetz CG, Tilley BC, Shaftman SR et al. Movement Disorder-society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale Presentation and Clinimetric Testing Results. Movement Disorders. 2008;23(15):2120-70.
  16. Cancela JM, Ayan C, Gutierrez-Santiago A et al. The Senior Fitness Test as a functional measure in Parkinson's disease: A pilot study. Parkinsonisom relat Disord. 2012;18(2):170-73. https://doi.org/10.1016/j.parkreldis.2011.09.016
  17. Lee HY, Kang DY, Kim K. Analysis of Correlation between Respiratory Characteristics and Physical Factors in Healthy Elementary School Childhood. The Journal of Korean Society of Physical Therapy. 2013;25(5):330-36.
  18. Sathyaprabha TN, Kapavarapu PK, Pal PK. Pulmonary Functions in Parkinsons's Disease. Indian J Chest Dis Allied Sci. 2005;47(4):251-58.
  19. Rikli RE, Jones CJ. Senior Fitness Test Manual 2th ed. United States. Human Kinetics. 2012: 17-22.
  20. Kim YN. Comparison of Effectiveness of Breathing Intervention Program for Improvement of Pulmonary Functions according to Prevalence Period in Patients with COPD. J Korean Soc Phys Ther. 2012;24(5): 355-61.
  21. Jankovic J. Parkinson's Disease: Clinical Feature and Diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368-76. https://doi.org/10.1136/jnnp.2007.131045
  22. Mikaeele H, Arami MA, Marndi MY. Respiratory Problems in Parkinson Disease. Clinical Pulmonary Medicine. 2009;16(3):139-43. https://doi.org/10.1097/CPM.0b013e3181a3b382
  23. Sabate M, Rodriguez M, Mendez E et al. Obstructive and Restrictive Pulmonary Dysfunction Increases Disability in Parkinson Disease. Arch Phys Med Rehabil. 1996;77(1):29-34. https://doi.org/10.1016/S0003-9993(96)90216-6
  24. Pitts T, Bolser D, Rosenbek J et al. Impact of Expiratory Muscle Strength Training on Voluntary Cough and Swallow Function in Parkinson Disease. Chest. 2009;135(5):1301-08. https://doi.org/10.1378/chest.08-1389
  25. Pandis MF, Starace A, Stefanelli F et al. Modification of Respiratory Function Parameters in Patients with Severe Parkinson's Disease. Neurol Sci. 2002;23:S69-S70. https://doi.org/10.1007/s100720200074
  26. Berardelli A, Rothwell JC, Thompson PD et al. Pathopahysiology of Bradykinesia in Parkinson's Disease. Brain. 2001;124:2131-46. https://doi.org/10.1093/brain/124.11.2131
  27. Troche MS, Okun MS, Rosenbek JC et al. Aspiration and Swallowing in Parkinson disease and Rehabilitation with EMST: A randomized trial. Neurology. 2010;75(21):1912-19. https://doi.org/10.1212/WNL.0b013e3181fef115