YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-platelet Effects of Mixtures of Onion and Aloe Extract

양파와 알로에 복합물이 혈소판 응집에 미치는 영향

  • Lee, Bo Kyung (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon) ;
  • Lee, Do-Seop (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon) ;
  • Ha, Soyoung (Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University) ;
  • Park, Se Won (Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University) ;
  • Jung, Yi-Sook (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon)
  • 이보경 (아주대학교 약학대학 병태생리학교실) ;
  • 이도섭 (아주대학교 약학대학 병태생리학교실) ;
  • 하소영 (건국대학교 생명환경과학대학) ;
  • 박세원 (건국대학교 생명환경과학대학) ;
  • 정이숙 (아주대학교 약학대학 병태생리학교실)
  • Received : 2014.09.19
  • Accepted : 2014.09.30
  • Published : 2014.10.31
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Abstract

In this study, we investigated whether the mixtures of onion water extract and aloe ethanol extracts have antiplatelet activities. The mixtures inhibited collagen- and thrombin-induced rat platelet aggregation in vitro. Additionally, the oral administration of the mixtures inhibited platelet aggregation induced by collagen ex vivo but not prolonged mouse tail vein bleeding time in vivo. These results suggest that the combination of onion and aloe extracts has a potential to be a preventive agent against platelet-mediated disorders.

Keywords

References

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