YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Water and Ethanol Extracts Codonopsis lanceolata on Spatial Learning and Memory in Mice

더덕 물 추출물과 에탄올 추출물의 인지능 개선 활성 비교

  • Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Jung, Youn Sik (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Ko, Hyun-Jeong (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University) ;
  • Lee, Hyeon Yong (Department of Teaics, Seowon University) ;
  • Park, Dong-Sik (Functional Food & Nutrition Division, Department of Agrofood Resources) ;
  • Chung, Hee-Chul (Newtree CO., LTD.) ;
  • Chung, Jae Youn (Newtree CO., LTD.) ;
  • Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
  • 원진배 (강원대학교 생물의소재공학과) ;
  • 이지우 (강원대학교 생물의소재공학과) ;
  • 엄민례 (강원대학교 생물의소재공학과) ;
  • 정윤식 (강원대학교 생물의소재공학과) ;
  • 고현정 (강원대학교 약학대학) ;
  • 이현용 (서원대학교 차학과(식품공학과)) ;
  • 박동식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 정희철 ((주)뉴트리) ;
  • 정재윤 ((주)뉴트리) ;
  • 마충제 (강원대학교 생물의소재공학과)
  • Received : 2014.03.04
  • Accepted : 2014.09.17
  • Published : 2014.10.31
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Abstract

Alzheimer's disease (AD), most common form of dementia is characterized that memory deficit and loss of cognitive function. This study was evaluated cognitive enhancing effect of water and ethanol extracts of Codonopsis lanceolata and compared using Morris water maze and passive avoidance test. The water and 70% ethanol extracts (100, 300 and 500 mg/kg) were administered to mice. The neuroprotective effect on glutamate-induced cell death in HT22 cells was additionally investigated using MTT assay. Results showed 70% ethanol extract of Codonopsis lanceolata enhanced cognitive function than water extract, as shown by decrease in escape latency time in Morris water maze test. In passive avoidance test, 70% ethanol extract also increased the latency time compared to the water extract. Furthermore, 70% ethanol extract significantly protected neuronal cell against glutamate cytotoxicity and showed higher than neuroprotective effect of water extract. These results indicate that 70% ethanol extract more improve spatial cognitive ability and protected neuronal cells than water extract.

Keywords

References

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