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A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in an Adult Presenting with an Extramedullary Bone Tumor

골수 외 골 종괴를 동반한 필라델피아 염색체 양성 급성 림프모구백혈병

  • Lee, Ho Jin (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Hye Jung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, In Chul (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Ji Hyun (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Sung-Hyun (Department of Internal Medicine, Dong-A University College of Medicine)
  • 이호진 (동아대학교 의과대학 내과학교실) ;
  • 이혜정 (동아대학교 의과대학 내과학교실) ;
  • 박인철 (동아대학교 의과대학 내과학교실) ;
  • 이지현 (동아대학교 의과대학 내과학교실) ;
  • 김성현 (동아대학교 의과대학 내과학교실)
  • Received : 2013.10.01
  • Accepted : 2013.10.29
  • Published : 2014.07.01

Abstract

Acute lymphoblastic leukemia (ALL) is a lymphoid malignancy characterized by impaired differentiation and proliferation of leukemic myeloblasts. Normal hematopoietic cells are replaced by excess myeloblasts, causing bone marrow failure. Therefore, patients with ALL typically present with symptoms related to infection, anemia, and thrombocytopenia. Extramedullary involvement of ALL as an initial presenting symptom has rarely been reported in adults, although several such cases of relapse have been described. Isolated extramedullary manifestations may lead to a late diagnosis of ALL. We describe herein a patient with Philadelphia chromosome-positive ALL presenting with an extramedullary bone tumor.

본 증례에서 저자들은 주기적인 혈액 검사에서 정상소견을 유지하였고 백혈병의 골수 외 침범으로 인한 무릎의 통증 이외 특이소견을 보이지 않았던 급성 림프모구백혈병 환자의 사례를 국내에서 경험하였기에 보고하는 바이다.

Keywords

References

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