The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Cushing's Syndrome Caused by an ACTH-Producing Neuroendocrine Carcinoma of the Gallbladder

쿠싱 증후군으로 발현한 이소성 ACTH 분비 담낭 신경내분비암종

  • Park, Sangwoo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Myung-Hwan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jin Hee (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Tae-Oh (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Tae Hyung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • So, Hoonsub (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sung Koo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 박상우 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김명환 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김진희 (울산대학교 의과대학 서울아산병원 영상의학과) ;
  • 김태오 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김태형 (울산대학교 의과대학 서울아산병원 내과) ;
  • 소훈섭 (울산대학교 의과대학 서울아산병원 내과) ;
  • 이성구 (울산대학교 의과대학 서울아산병원 내과)
  • Received : 2013.12.12
  • Accepted : 2014.01.07
  • Published : 2014.07.01
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Abstract

Neuroendocrine tumors of the gallbladder are rare, and typically found incidentally after a cholecystectomy. Few data are available on adrenocorticotrophic hormone (ACTH)-producing neuroendocrine tumors originating specifically from the gallbladder. We experienced the case of a patient with a gallbladder mass who presented with Cushing's syndrome, who was subsequently diagnosed as an ACTH-producing neuroendocrine carcinoma of the gallbladder. Despite being rare, hormone-producing neuroendocrine tumors should be part of the differential diagnosis in patients with Cushing's syndrome.

이 증례에서 영상 검사 및 조직 검사를 통해 담낭 신경내분비암종을 진단하였으며, 호르몬 검사 및 면역조직화학 염색으로 담낭 신경내분비암종에 의한 이소성 ACTH 분비 쿠싱 증후군을 확인할 수 있었다. 이소성 ACTH 분비가 있으나 그 원인이 뚜렷하지 않은 쿠싱 증후군 환자에서 신경내분비종양이 존재한다면 신경내분비종양이 이소성 ACTH 증후군을 일으킬 수 있는 가능한 원인 중의 하나로서 고려되어야 할 것이다.

Keywords

References

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