The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of T-Lymphoblastic Lymphoma/Leukemia with Bilateral Primary Adrenal Involvement

양측성 원발성 부신 침범의 T-림프모구백혈병/림프종 1예

  • Jung, Chul Min (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Song, Seo-Young (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Kim, Sun Wook (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Lee, Dong Hyun (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Jung, Hochul (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Lee, Ho Jin (Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Ryu, Youngjoon (Department of Pathology, Kangwon National University Hospital, Kangwon National University School of Medicine)
  • 정철민 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 송서영 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 김선욱 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 이동현 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 정호철 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 이호진 (강원대학교 의학전문대학원 강원대학교병원 내과) ;
  • 류영준 (강원대학교 의학전문대학원 강원대학교병원 병리과)
  • Received : 2013.08.06
  • Accepted : 2013.10.02
  • Published : 2014.06.01
⟨ Previous Next ⟩

Abstract

T-lymphoblastic leukemia/lymphoma is an aggressive condition with frequent involvement of the mediastinum, occurring most frequently in older children, adolescents, and young adults. The involvement of extranodal sites is less common, and abdominal dissemination is unusual, but when present it primarily involves the liver and spleen. However, primary lymphoma of the adrenal glands is rare. The majority of reported cases presented with a B-cell immunophenotype. Herein, we report the case of a patient with T-lymphoblastic leukemia/lymphoma who presented predominantly with bilateral adrenal masses without lymphadenopathy, and whose clinical course deteriorated rapidly.

현재까지 성인에서 보고된 부신의 원발 림프종은 B세포에서 기원하는 경우가 드물게 보고되었다. 저자들은 복통을 주소로 내원한 51세 여자 환자에서 양측 부신의 종괴를 확인하였고 이후 DIC가 동반되는 급격한 임상 경과를 보인 T-림프모구백혈병/림프종을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Borowitz MJ, Chan JK. T-lymhoblastic leukaemia/lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, eds. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: International Agency for Research on Cancer, 2008: 176-178.
  2. Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D. Lymphoblastic lymphoma. Crit Rev Oncol Hematol 2011;79:330-343. https://doi.org/10.1016/j.critrevonc.2010.12.003
  3. Knowles DM. Lymphoblastic lymphoma. In: Knowles DM, ed. Neoplastic Hematopathology. Baltimore: Williams & Wilkins, 1992:715-747.
  4. Tomoyose T, Nagasaki A, Uchihara JN, et al. Primary adrenal adult T-cell leukemia/lymphoma: a case report and review of the literature. Am J Hematol 2007;82:748-752. https://doi.org/10.1002/ajh.20856
  5. Barcos MP, Lukes RJ. Malignant lymphoma of convoluted lymphocytes: a new entity of possible T-cell type. In: Sinks LF, Godden JO, eds. Conflicts in Childhood Cancer: an Evaluation of Current Management. New York: Liss, 1975;14:147-148.
  6. Wang J, Sun NC, Renslo R, et al. Clinically silent primary adrenal lymphoma: a case report and review of the literature. Am J Hematol 1998;58:130-136. https://doi.org/10.1002/(SICI)1096-8652(199806)58:2<130::AID-AJH8>3.0.CO;2-T
  7. Singh D, Kumar L, Sharma A, Vijayaraghavan M, Thulkar S, Tandon N. Adrenal involvement in non-Hodgkin's lymphoma: four cases and review of literature. Leuk Lymphoma 2004;45:789-794. https://doi.org/10.1080/10428190310001615756
  8. Park KK, Jang YS, Lee HS, Song HS, Park SK. A case of bilateral primary adrenal lymphoma. Korean J Med 2000;59:447-451.
  9. Rashidi A, Fisher SI. Primary adrenal lymphoma: a systematic review. Ann Hematol 2013;92:1583-1593. https://doi.org/10.1007/s00277-013-1812-3
  10. Nur S, Anwar M, Saleem M, Ahmad PA. Disseminated intravascular coagulation in acute leukaemias at first diagnosis. Eur J Haematol 1995;55:78-82.