The Korean Journal of Medicine

  • 제86권3호
  • /
  • Pages.271-276
  • /
  • 2014
  • /
  • 1738-9364(pISSN)
  • /
  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지
DOI QR코드

DOI QR Code

중증열성혈소판감소증후군

Severe Fever with Thrombocytopenia Syndrome

  • 김계형 (서울대학교 의과대학 내과학교실) ;
  • 오명돈 (서울대학교 의과대학 내과학교실)
  • Kim, Kye-Hyung (Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Oh, Myoung-Don (Department of Internal Medicine, Seoul National University College of Medicine)
  • 발행 : 2014.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Severe fever with thrombocytopenia syndrome (SFTS) is firstly reported in China in 2011. It is an emerging infectious disease in China, Japan and South Korea. It is caused by novel bunyavirus, called SFTS virus. The vector of SFTS is Haemaphysalis longicornis tick and domesticated animals may serve as intermediate hosts. The clinical manifestations of SFTS are fever, vomiting, diarrhea, thrombocytopenia and leukopenia. In severe cases, multiple organ failure, disseminated intravascular coagulopathy, and central nervous systems manifestation are present. The case-fatality rate is 6-30%. There is no effective antiviral therapy and supportive care is the main treatment.

키워드

참고문헌

  1. Jones KE, Patel NG, Levy MA, et al. Global trends in emerging infectious diseases. Nature 2008;451:990-993. https://doi.org/10.1038/nature06536
  2. Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 2011;364:1523-1532. https://doi.org/10.1056/NEJMoa1010095
  3. Ding F, Zhang W, Wang L, et al. Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011-2012. Clin Infect Dis 2013;56:1682-1683. https://doi.org/10.1093/cid/cit100
  4. Zhang YZ, He YW, Dai YA, et al. Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis 2012;54:527-533. https://doi.org/10.1093/cid/cir804
  5. Gai ZT, Zhang Y, Liang MF, et al. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis 2012;206:1095-1102. https://doi.org/10.1093/infdis/jis472
  6. Takahashi T, Maeda K, Suzuki T, et al. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 2013 Dec 12 [Epub]. http://dx.doi.org/10.1093/infdis/jit603.
  7. Kim KH, Yi J, Kim G, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 2013;19:1892-1894.
  8. Elliott RM. Emerging viruses: the Bunyaviridae. Mol Med 1997;3:572-577.
  9. Liu Y, Li Q, Hu W, et al. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 2012;12:156-160. https://doi.org/10.1089/vbz.2011.0758
  10. Korea Centers for Disease Control and Prevention. A current state of confirmed cases of severe fever with thrombocytopenia syndrome in Korea (Nov 28, 2013) [Internet]. Osong: Korea Centers for Disease Control and Prevention, c2013 [cited 2014 Feb 17]. Available from: http://cdc.go.kr/CDC/intro/CdcKrIntro0201.jsp?menuIds=HOME001-MNU1154-MNU0005-MNU0011&cid=21944.
  11. Zhang YZ, Zhou DJ, Qin XC, et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol 2012;86:2864-2868. https://doi.org/10.1128/JVI.06192-11
  12. Zhao L, Zhai S, Wen H, et al. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 2012;18:963-965.
  13. Niu G, Li J, Liang M, et al. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 2013;19:756-763.
  14. Chae JS, Yu do H, Shringi S, et al. Microbial pathogens in ticks, rodents and a shrew in northern Gyeonggi-do near the DMZ, Korea. J Vet Sci 2008;9:285-293. https://doi.org/10.4142/jvs.2008.9.3.285
  15. Kim CM, Yi YH, Yu DH, et al. Tick-borne rickettsial pathogens in ticks and small mammals in Korea. Appl Environ Microbiol 2006;72:5766-5776. https://doi.org/10.1128/AEM.00431-06
  16. Korea Centers for Disease Control and Prevention. Prevention of severe fever with thrombocytopenia syndrome in Korean [Internet]. Osong: Korea Centers for Disease Control and Prevention, c2013 [cited 2014 Feb 17]. Available from: http://cdc.go.kr/CDC/intro/CdcKrIntro0201.jsp?menuIds=HOME001-MNU1154-MNU0005-MNU0011&cid=20790.
  17. Tang X, Wu W, Wang H, et al. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 2013;207:736-739. https://doi.org/10.1093/infdis/jis748
  18. Chen H, Hu K, Zou J, Xiao J. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 2013;17:e206-208. https://doi.org/10.1016/j.ijid.2012.11.006
  19. Gai Z, Liang M, Zhang Y, et al. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 2012;54:249-252. https://doi.org/10.1093/cid/cir776
  20. Bao CJ, Guo XL, Qi X, et al. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis 2011;53:1208-1214. https://doi.org/10.1093/cid/cir732
  21. Deng B, Zhang S, Geng Y, et al. Cytokine and chemokine levels in patients with severe fever with thrombocytopenia syndrome virus. PLoS One 2012;7:e41365. https://doi.org/10.1371/journal.pone.0041365
  22. Sun Y, Jin C, Zhan F, et al. Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis 2012;206:1085-1094. https://doi.org/10.1093/infdis/jis452
  23. Jin C, Liang M, Ning J, et al. Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci USA 2012;109:10053-10058. https://doi.org/10.1073/pnas.1120246109
  24. Shin J. Epidemiologic characteristics of Korean patients with severe fever with thrombocytopenia syndrome. Proceeding of 2013 the Communicable Disease Control Conference; 2013 Nov 21-22; Yeosu: Korea Center for Disease Control and Prevention, 2013:11-16.
  25. Xu B, Liu L, Huang X, et al. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog 2011;7:e1002369. https://doi.org/10.1371/journal.ppat.1002369
  26. Zhang YZ, Zhou DJ, Xiong Y, et al. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi 2011;32:209-220.
  27. Liu W, Lu QB, Cui N, et al. Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome. Clin Infect Dis 2013;57:1292-1299. https://doi.org/10.1093/cid/cit530
  28. Quantai X, Fengzhe C, Xiuguang S, Dongge C. A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. PLoS One 2013;8:e83020. https://doi.org/10.1371/journal.pone.0083020
  29. Korea Centers for Disease Control and Prevention. Case Definition for National Notifiable Infectious Diseases in Korean [Internet]. Osong: Korea Centers for Disease Control and Prevention, c2014 [cited 2014 Feb 18]. Availabel from: http://www.cdc.go.kr/CDC/together/CdcKrTogether0302.jsp?menuIds=HOME001-MNU1154-MNU0004-MNU0088&fid=51&q_type=&q_value=&cid=22130&pageNum=.
  30. Sun L, Hu Y, Niyonsaba A, et al. Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome. Clin Exp Med 2013 Sep 26 [Epub]. http://dx.doi.org/10.1007/s10238-013-0259-0.
  31. Jiao Y, Zeng X, Guo X, et al. Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. J Clin Microbiol 2012;50:372-377. https://doi.org/10.1128/JCM.01319-11
  32. Dumler JS, Choi KS, Garcia-Garcia JC, et al. Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg Infect Dis 2005;11:1828-1834. https://doi.org/10.3201/eid1112.050898
  33. Zhang L, Liu Y, Ni D, et al. Nosocomial transmission of human granulocytic anaplasmosis in China. JAMA 2008;300:2263-2270. https://doi.org/10.1001/jama.2008.626
  34. Ohashi N, Gaowa, Wuritu, et al. Human granulocytic Anaplasmosis, Japan. Emerg Infect Dis 2013;19:289-292. https://doi.org/10.3201/eid1902.120855
  35. Chae JS, Kim CM, Kim EH, et al. Molecular epidemiological study for tick-borne disease (Ehrlichia and Anaplasma spp.) surveillance at selected U.S. military training sites/installations in Korea. Ann N Y Acad Sci 2003;990:118-125. https://doi.org/10.1111/j.1749-6632.2003.tb07349.x
  36. Kang JG, Ko S, Kim YJ, et al. New genetic variants of Anaplasma phagocytophilum and Anaplasma bovis from Korean water deer (Hydropotes inermis argyropus). Vector Borne Zoonotic Dis 2011;11:929-938. https://doi.org/10.1089/vbz.2010.0214
  37. ProMedmail. Anaplasmosis-South Korea: (KW) 1st clinical case description [Internet]. Boston: ProMedmail, c2013 [cited 2014 Feb 18]. Available from: http://www.promedmail.org.
  38. Peters CJ, Simpson GL, Levy H. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Annu Rev Med 1999;50:531-545. https://doi.org/10.1146/annurev.med.50.1.531
  39. Levett PN. Leptospirosis. Clin Microbiol Rev 2001;14:296-326. https://doi.org/10.1128/CMR.14.2.296-326.2001

피인용 문헌

  1. Distribution and Detection of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks Collected from Jeollanam-do, Korea vol.46, pp.2, 2014, https://doi.org/10.4167/jbv.2016.46.2.93
  2. 지리산둘레길에서 채집한 참진드기의 분포와 참진드기에서의 중증열성혈소판감소증후군바이러스 검출 vol.39, pp.2, 2014, https://doi.org/10.7853/kjvs.2016.39.2.75
  3. 산해박 뿌리에서 추출한 정유 및 구성성분의 인간 장내미생물에 대한 항균활성 및 작은소피참진드기에 대한 살비활성 vol.61, pp.4, 2018, https://doi.org/10.3839/jabc.2018.060
  4. 2019년 경북 상주 지역 환경별 참진드기 분포 조사 및 중증열성혈소판감소증후군 바이러스 검출 vol.59, pp.3, 2014, https://doi.org/10.5656/ksae.2020.06.0.019
  5. 대전 주택가 산책로 진드기의 인수공통전염병 병원체 감염실태 조사 vol.44, pp.2, 2014, https://doi.org/10.7853/kjvs.2021.44.2.93
  6. Therapeutic Plasma Exchange in Patients with Severe Fever with Thrombocytopenia Syndrome: A Single Institution Experience vol.32, pp.2, 2014, https://doi.org/10.17945/kjbt.2021.32.2.83