The Korean Journal of Medicine

  • 제86권4호
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  • Pages.510-514
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  • 2014
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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중증 재생불량성 빈혈에 대한 동종골수이식 후에 발생한 기증세포백혈병 1예

Case of Donor Cell Leukemia after Allogenic Bone Marrow Transplantation for Severe Aplastic Anemia

  • 김은정 (고신대학교복음병원 혈액내과) ;
  • 김양수 (고신대학교복음병원 혈액내과) ;
  • 이호섭 (고신대학교복음병원 혈액내과) ;
  • 이은미 (고신대학교복음병원 혈액내과) ;
  • 박이천 (고신대학교복음병원 혈액내과) ;
  • 이원형 (고신대학교복음병원 혈액내과) ;
  • 김미향 (고신대학교복음병원 진단검사의학과)
  • Kim, Eun Jeong (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Kim, Yang Soo (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Ho Seop (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Eun Mi (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Park, I Cheon (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Weon Hyoung (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Kim, Mi Hyang (Department of Laboratory Medicine, Kosin University Gospel Hospital)
  • 투고 : 2013.06.06
  • 심사 : 2013.09.01
  • 발행 : 2014.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

본 증례는 중증재생불량성빈혈 환자에서 동종 조혈모세포이식 후 발생한 기증세포백혈병에 관한 보고이다. 기증세포백혈병은 드문 질환이지만 동종 조혈모세포이식 후 발생할 수 있는 합병증 중의 하나로 잘 알려져 있으며 진단에 있어서 세포유전적 분석 외에도 최근 short tandem repeats (STR) 혹은 variable number of tandem repeats (VNTR) 등의 분자적 분석기술의 발달로 진단이 용이해질 수 있다. 국내에서는 중증재생불량성빈혈 환자에서 동종골수이식 후에 발생한 기증세포기원의 급성 림프구성 백혈병이 보고된 바가 없고 저자들이 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Globally, there have been a small number of donor cell leukemia cases reported but, to our knowledge, none have been reported in Korea until now. Donor cell leukemia is a rare though well-recognized complication that occurs after allogenic hematopoietic stem cell transplantation (allo-HSCT). Herein, we report the case of an 18-year-old woman who developed acute lymphoblastic leukemia originating from donor cells after allo-HSCT.

키워드

참고문헌

  1. Deeg JH. Delayed complications after bone marrow transplantation. In: Forman SJ, Blume KG, Thomas ED, eds. Bone marrow transplantation. Boston: Blackwell, 1994:538-544.
  2. Fialkow PJ, Thomas ED, Bryant JI, Neiman PE. Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1971;1:251-255.
  3. Hertenstein B, Hambach L, Bacigalupo A, et al. Development of leukemia in donor cells after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2005;90:969-975.
  4. Perla G, Bodenizza C, Falcone A, et al. Misleading cytogenetic evidence of relapse in donor cells after allogeneic bone marrow transplantation corrected by fluorescent in situ hybridization. Haematologica 1995;80:292-293.
  5. Naoe T, Kiyoi H, Yamanaka K, Naito K, Yamada K. A case of cALL relapse after allogeneic BMT: recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. Br J Haematol 1989;73:420-422. https://doi.org/10.1111/j.1365-2141.1989.tb07766.x
  6. Spinelli O, Giussani U, Borleri G, et al. Need for an accurate molecular diagnosis to assess the donor origin of leukemia relapse after allogeneic stem cell transplantation. Haematologica 2000;85:1153-1157.
  7. Murata M, Ishikawa Y, Ohashi H, et al. Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Int J Hematol 2008;88:111-115. https://doi.org/10.1007/s12185-008-0094-3
  8. Ruiz-Arguelles A. Donor cell leukemia. Hematology 2012;17(Suppl 1):69-71.

피인용 문헌

  1. A Case of Donor Cell Leukemia after Allogenic Peripheral Blood Stem Cell Transplantation for Acute Promyelocytic Leukemia with PML-RARA vol.10, pp.1, 2014, https://doi.org/10.3343/lmo.2020.10.1.88