The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Case of Donor Cell Leukemia after Allogenic Bone Marrow Transplantation for Severe Aplastic Anemia

중증 재생불량성 빈혈에 대한 동종골수이식 후에 발생한 기증세포백혈병 1예

  • Kim, Eun Jeong (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Kim, Yang Soo (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Ho Seop (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Eun Mi (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Park, I Cheon (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Lee, Weon Hyoung (Division of Hematology, Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Kim, Mi Hyang (Department of Laboratory Medicine, Kosin University Gospel Hospital)
  • 김은정 (고신대학교복음병원 혈액내과) ;
  • 김양수 (고신대학교복음병원 혈액내과) ;
  • 이호섭 (고신대학교복음병원 혈액내과) ;
  • 이은미 (고신대학교복음병원 혈액내과) ;
  • 박이천 (고신대학교복음병원 혈액내과) ;
  • 이원형 (고신대학교복음병원 혈액내과) ;
  • 김미향 (고신대학교복음병원 진단검사의학과)
  • Received : 2013.06.06
  • Accepted : 2013.09.01
  • Published : 2014.04.01
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Abstract

Globally, there have been a small number of donor cell leukemia cases reported but, to our knowledge, none have been reported in Korea until now. Donor cell leukemia is a rare though well-recognized complication that occurs after allogenic hematopoietic stem cell transplantation (allo-HSCT). Herein, we report the case of an 18-year-old woman who developed acute lymphoblastic leukemia originating from donor cells after allo-HSCT.

본 증례는 중증재생불량성빈혈 환자에서 동종 조혈모세포이식 후 발생한 기증세포백혈병에 관한 보고이다. 기증세포백혈병은 드문 질환이지만 동종 조혈모세포이식 후 발생할 수 있는 합병증 중의 하나로 잘 알려져 있으며 진단에 있어서 세포유전적 분석 외에도 최근 short tandem repeats (STR) 혹은 variable number of tandem repeats (VNTR) 등의 분자적 분석기술의 발달로 진단이 용이해질 수 있다. 국내에서는 중증재생불량성빈혈 환자에서 동종골수이식 후에 발생한 기증세포기원의 급성 림프구성 백혈병이 보고된 바가 없고 저자들이 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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  1. A Case of Donor Cell Leukemia after Allogenic Peripheral Blood Stem Cell Transplantation for Acute Promyelocytic Leukemia with PML-RARA vol.10, pp.1, 2014, https://doi.org/10.3343/lmo.2020.10.1.88