The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Etoposide Therapy in a Patient Newly Diagnosed with Classic Kaposi's Sarcoma and Rheumatoid Arthritis

류마티스관절염이 동반된 고전형 카포시육종의 에토포사이드 치료 1예

  • Choi, Nan Young (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Park, Seung Ah (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Han, Bo Ram (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Kim, Ho Young (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Min, Soo Kee (Departments of Pathology, Hallym University College of Medicine) ;
  • Kim, Hyo Jung (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Zang, Dae Young (Department of Internal Medicine, Hallym University College of Medicine)
  • 최난영 (한림대학교 의과대학 내과학교실) ;
  • 박승아 (한림대학교 의과대학 내과학교실) ;
  • 한보람 (한림대학교 의과대학 내과학교실) ;
  • 김호영 (한림대학교 의과대학 내과학교실) ;
  • 민수기 (한림대학교 의과대학 병리학교실) ;
  • 김효정 (한림대학교 의과대학 내과학교실) ;
  • 장대영 (한림대학교 의과대학 내과학교실)
  • Received : 2013.04.27
  • Accepted : 2013.09.01
  • Published : 2014.02.01
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Abstract

Kaposi's sarcoma typically occurs in immunocompromised patients, especially those with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) and human immunodeficiency virus (HIV) may play important roles in the development of Kaposi's sarcoma. We report the case of a 75-year-old male who presented with progressive multiple purplish papules and nodules on the skin for 3 months. Social and past medical histories seemed incompatible with an immunesuppressed condition and tests for HIV antibodies and HHV-8 were negative. He was newly diagnosed with rheumatoid arthritis, according to the 2010 ACR-EULAR criteria. Typical findings of Kaposi's sarcoma were confirmed by biopsy. After treatment with metronomic oral etoposide 25 mg once daily for 9 months, the skin lesions had almost resolved with no serious complication. Thus, we report a rare case of Kaposi's sarcoma developing in a patient with newly diagnosed rheumatoid arthritis who showed a good response to oral etoposide.

본 저자들은 류마티스관절염을 처음 진단받고 면역저하의 증거가 없으며 HHV-8 음성이며 전신상태가 좋지 않은 고령의 환자에서 전신 피부에 발생한 4병기 고전형 카포시육종을 진단하였고 지속적인 저용량 경구 에토포사이드 단독요법으로 좋은 임상경과를 얻은 증례가 있어 보고하는 바이다.

Keywords

References

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