The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Acute Myeloid Leukemia with Persistent Marrow Aplasia after Chemotherapy Treated with Reduced-Intensity Allogeneic Stem Cell Transplantation

동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후 골수 무형성증 1예

  • Yoon, Hyunhwa (Departments of Internal Medicine, Gachon University School of Medicine) ;
  • Hong, Junshik (Departments of Internal Medicine, Gachon University School of Medicine) ;
  • Kim, Suyoung (Departments of Internal Medicine, Gachon University School of Medicine) ;
  • Lee, Dongmin (Departments of Internal Medicine, Gachon University School of Medicine) ;
  • Park, Jinny (Departments of Internal Medicine, Gachon University School of Medicine) ;
  • Ahn, Jeong Yeal (Departments of Laboratory Medicine, Gachon University School of Medicine) ;
  • Lee, Jae Hoon (Departments of Internal Medicine, Gachon University School of Medicine)
  • 윤현화 (가천대학교 의학전문대학원 내과) ;
  • 홍준식 (가천대학교 의학전문대학원 내과) ;
  • 김수영 (가천대학교 의학전문대학원 내과) ;
  • 이동민 (가천대학교 의학전문대학원 내과) ;
  • 박진희 (가천대학교 의학전문대학원 내과) ;
  • 안정열 (가천대학교 의학전문대학원 진단검사의학과) ;
  • 이재훈 (가천대학교 의학전문대학원 내과)
  • Received : 2013.03.18
  • Accepted : 2013.08.12
  • Published : 2014.02.01
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Abstract

Persistent bone marrow aplasia after intensive chemotherapy is uncommon, but is one of the fatal complications in patients with acute myeloid leukemia (AML). Although allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be contraindicated for patients who have hematologic diseases with serious infections, such as bacterial septicemia or invasive fungal diseases, combined with prolonged neutropenia due to frequent morbidity and mortality, such risks can be overcome by non-myeloablative conditioning and best supportive care. Here, we report an AML patient with persistent marrow aplasia after induction therapy, treated successfully with reduced-intensity allogeneic HSCT despite severe bacterial and fungal infections.

급성 골수성 백혈병에서 고용량 항암화학요법 후 발생하는 지속성 골수 무형성증은 높은 이환율과 사망률을 나타낼 수 있는 매우 드문 합병증으로 더욱이 감염까지 동반한 경우는 일반적으로 조혈모세포이식의 금기이나 전문적인 감염치료를 병행하면서 비골수억제성 전처치로 조혈모세포이식을 적극 고려해야 한다.

Keywords

References

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