Korean Journal of Radiology

  • 제15권2호
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  • Pages.218-225
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  • 2014
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
DOI QR코드

DOI QR Code

Hepatic Sinusoidal Obstruction Syndrome Caused by Herbal Medicine: CT and MRI Features

  • Zhou, Hua (Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Wang, Yi-Xiang J. (Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital) ;
  • Lou, Hai-Yan (Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Xu, Xiao-Jun (Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Zhang, Min-Ming (Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine)
  • 투고 : 2013.02.18
  • 심사 : 2013.12.07
  • 발행 : 2014.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To describe the CT and MRI features of hepatic sinusoidal obstruction syndrome (HSOS) caused by herbal medicine Gynura segetum. Materials and Methods: The CT and MRI features of 16 consecutive Gynura segetum induced HSOS cases (12 men, 4 women) were analyzed. Eight patients had CT; three patients had MRI, and the remaining five patients had both CT and MRI examinations. Based on their clinical presentations and outcomes, the patients were classified into three categories: mild, moderate, and severe. The severity of the disease was also evaluated radiologically based on the abnormal hepatic patchy enhancement in post-contrast CT or MRI images. Results: Ascites, patchy liver enhancement, and main right hepatic vein narrowing or occlusion were present in all 16 cases. Hepatomegaly and gallbladder wall thickening were present in 14 cases (87.5%, 14/16). Periportal high intensity on T2-weighted images was present in 6 cases (75%, 6/8). Normal liver parenchymal enhancement surrounding the main hepatic vein forming a clover-like sign was observed in 4 cases (25%, 4/16). The extent of patchy liver enhancement was statistically associated with clinical severity classification (kappa = 0.565). Conclusion: Ascites, patchy liver enhancement, and the main hepatic veins narrowing were the most frequent signs of herbal medicine induced HSOS. The grade of abnormal patchy liver enhancement was associated with the clinical severity.

키워드

참고문헌

  1. Helmy A. Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome. Aliment Pharmacol Ther 2006;23:11-25 https://doi.org/10.1111/j.1365-2036.2006.02742.x
  2. Wilmont FC, Robertson GW. Senecio disease, or cirrhosis of the liver due to senecio poisoning. Lancet 1920;196:848-849 https://doi.org/10.1016/S0140-6736(01)00020-4
  3. Zuckerman M, Steenkamp V, Stewart MJ. Hepatic venoocclusive disease as a result of a traditional remedy: confirmation of toxic pyrrolizidine alkaloids as the cause, using an in vitro technique. J Clin Pathol 2002;55:676-679 https://doi.org/10.1136/jcp.55.9.676
  4. Kakar F, Akbarian Z, Leslie T, Mustafa ML, Watson J, van Egmond HP, et al. An outbreak of hepatic veno-occlusive disease in Western afghanistan associated with exposure to wheat flour contaminated with pyrrolizidine alkaloids. J Toxicol 2010;2010:313280
  5. Ortiz Cansado A, Crespo Valades E, Morales Blanco P, Saenz de Santamaria J, Gonzalez Campillejo JM, Ruiz Tellez T. [Venoocclusive liver disease due to intake of Senecio vulgaris tea]. Gastroenterol Hepatol 1995;18:413-416
  6. Kumar S, DeLeve LD, Kamath PS, Tefferi A. Hepatic venoocclusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc 2003;78:589-598 https://doi.org/10.4065/78.5.589
  7. Alpert LI. Veno-occlusive disease of the liver associated with oral contraceptives: case report and review of literature. Hum Pathol 1976;7:709-718 https://doi.org/10.1016/S0046-8177(76)80082-2
  8. Fajardo LF, Colby TV. Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med 1980;104:584-588
  9. Lin G, Wang JY, Li N, Li M, Gao H, Ji Y, et al. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol 2011;54:666-673 https://doi.org/10.1016/j.jhep.2010.07.031
  10. Dai HF, Gao Y, Yang M, Yu CH, Gu ZY, Chen WX. Hepatic venoocclusive disease induced by Gymura segetum: report of two cases. Hepatobiliary Pancreat Dis Int 2006;5:406-408
  11. Chen Z, Huo JR. Hepatic veno-occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations. Neth J Med 2010;68:252-260
  12. Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation 1987;44:778-783 https://doi.org/10.1097/00007890-198712000-00011
  13. McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 1984;4:116-122 https://doi.org/10.1002/hep.1840040121
  14. Wu XW, Wang WQ, Liu B, Xu JM, Yu YQ, Zhang S, et al. Hepatic veno-occlusive disease after taking Gynura Rhizome: the value of multidetector computed tomography in diagnosing the disease and evaluating the clinical therapeutic effect. Hepatol Res 2012;42:304-309 https://doi.org/10.1111/j.1872-034X.2011.00918.x
  15. van den Bosch MA, van Hoe L. MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation. Eur Radiol 2000;10:1290-1293 https://doi.org/10.1007/s003300000330
  16. Dumont Ch, Lambert M, Van Beers BE. MR imaging findings in a patient with hepatic veno-occlusive disease. Acta Gastroenterol Belg 2004;67:236-238
  17. Mortele KJ, Van Vlierberghe H, Wiesner W, Ros PR. Hepatic veno-occlusive disease: MRI findings. Abdom Imaging 2002;27:523-526 https://doi.org/10.1007/s00261-001-0097-5
  18. Gao H, Li N, Wang JY, Zhang SC, Lin G. Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. J Dig Dis 2012;13:33-39 https://doi.org/10.1111/j.1751-2980.2011.00552.x
  19. DeLeve LD, Valla DC, Garcia-Tsao G. Vascular disorders of the liver. Hepatology 2009;49:1729-1764 https://doi.org/10.1002/hep.22772
  20. Danan G, Benichou C. Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993;46:1323-1330 https://doi.org/10.1016/0895-4356(93)90101-6
  21. McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med 1993;118:255-267 https://doi.org/10.7326/0003-4819-118-4-199302150-00003
  22. Mahgerefteh SY, Sosna J, Bogot N, Shapira MY, Pappo O, Bloom AI. Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology 2011;258:660-671 https://doi.org/10.1148/radiol.10100025
  23. Gray H, Williams PL, Bannister LH. Gray's anatomy: the anatomical basis of medicine and surgery, 38th ed. New York: Churchill Livingstone, 1995:1902-1903
  24. Sharma D, Deshmukh A, Raina VK. Surgical anatomy of retrohepatic inferior vena cava and hepatic veins: a quantitative assessment. Indian J Gastroenterol 2001;20:136-139
  25. DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, et al. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 1999;29:1779-1791 https://doi.org/10.1002/hep.510290615
  26. Meresse V, Hartmann O, Vassal G, Benhamou E, Valteau- Couanet D, Brugieres L, et al. Risk factors for hepatic veno-occlusive disease after high-dose busulfancontaining regimens followed by autologous bone marrow transplantation: a study in 136 children. Bone Marrow Transplant 1992;10:135-141
  27. Ayash LJ, Hunt M, Antman K, Nadler L, Wheeler C, Takvorian T, et al. Hepatic venoocclusive disease in autologous bone marrow transplantation of solid tumors and lymphomas. J Clin Oncol 1990;8:1699-1706 https://doi.org/10.1200/JCO.1990.8.10.1699
  28. Erturk SM, Mortele KJ, Binkert CA, Glickman JN, Oliva MR, Ros PR, et al. CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol 2006;186:1497-1501 https://doi.org/10.2214/AJR.05.0539
  29. Ward J, Guthrie JA, Sheridan MB, Boyes S, Smith JT, Wilson D, et al. Sinusoidal obstructive syndrome diagnosed with superparamagnetic iron oxide-enhanced magnetic resonance imaging in patients with chemotherapy-treated colorectal liver metastases. J Clin Oncol 2008;26:4304-4310 https://doi.org/10.1200/JCO.2008.16.1893
  30. Shin NY, Kim MJ, Lim JS, Park MS, Chung YE, Choi JY, et al. Accuracy of gadoxetic acid-enhanced magnetic resonance imaging for the diagnosis of sinusoidal obstruction syndrome in patients with chemotherapy-treated colorectal liver metastases. Eur Radiol 2012;22:864-871 https://doi.org/10.1007/s00330-011-2333-x

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  3. Hepatotoxicity of herbal and dietary supplements: an update vol.89, pp.6, 2014, https://doi.org/10.1007/s00204-015-1471-3
  4. Cancer therapy related complications in the liver, pancreas, and biliary system: an imaging perspective vol.6, pp.6, 2014, https://doi.org/10.1007/s13244-015-0436-7
  5. Tusanqi-Related Sinusoidal Obstruction Syndrome in China : A Systematic Review of the Literatures vol.94, pp.23, 2014, https://doi.org/10.1097/md.0000000000000942
  6. Imaging of Drug-induced Complications in the Gastrointestinal System vol.36, pp.1, 2016, https://doi.org/10.1148/rg.2016150132
  7. Diagnostic performance of Contrast-enhanced CT in Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstructive Syndrome vol.6, pp.None, 2014, https://doi.org/10.1038/srep37998
  8. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantatio vol.51, pp.7, 2014, https://doi.org/10.1038/bmt.2016.130
  9. Hepatic Sinusoidal Dilatation: A Review of Causes With Imaging-Pathologic Correlation vol.37, pp.6, 2016, https://doi.org/10.1053/j.sult.2016.08.007
  10. Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication vol.12, pp.6, 2014, https://doi.org/10.1371/journal.pone.0179379
  11. Vascular diseases of the liver. Clinical Guidelines from the Catalan Society of Digestology and the Spanish Association for the Study of the Liver vol.40, pp.8, 2017, https://doi.org/10.1016/j.gastre.2017.03.014
  12. Non-cirrhotic portal hypertension: an imaging review vol.43, pp.8, 2014, https://doi.org/10.1007/s00261-018-1570-8
  13. Risk factors for hepatic veno-occlusive disease caused by Gynura segetum : a retrospective study vol.18, pp.None, 2014, https://doi.org/10.1186/s12876-018-0879-7
  14. A case of severe stenosis of hepatic veins and inferior vena cava with stomal variceal bleeding induced by oxaliplatin-based chemotherapy vol.11, pp.2, 2018, https://doi.org/10.1007/s12328-017-0814-4
  15. Gadoxetic Acid-Enhanced Hepatobiliary-Phase Magnetic Resonance Imaging for Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome and Association with Liver Function vol.9, pp.None, 2014, https://doi.org/10.1038/s41598-018-37775-1
  16. Quantitative Analysis of CT Images in Patients with Pyrrolizidine Alkaloid-Induced Sinusoidal Obstruction Syndrome vol.9, pp.None, 2019, https://doi.org/10.1038/s41598-019-38669-6
  17. Ayurveda Herbal Medicine-induced Liver Cirrhosis vol.11, pp.2, 2014, https://doi.org/10.7759/cureus.4122
  18. Expert consensus on the clinical management of pyrrolizidine alkaloid‐induced hepatic sinusoidal obstruction syndrome vol.34, pp.4, 2019, https://doi.org/10.1111/jgh.14612
  19. Role of imaging techniques in liver veno-occlusive disease diagnosis: recent advances and literature review vol.13, pp.5, 2014, https://doi.org/10.1080/17474124.2019.1588111
  20. Hepatic disorders associated with exogenous sex steroids: MR imaging findings vol.44, pp.7, 2014, https://doi.org/10.1007/s00261-019-01941-4
  21. CT of acute rejection after liver transplantation: a matched case-control study vol.29, pp.7, 2014, https://doi.org/10.1007/s00330-018-5971-4
  22. Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes vol.25, pp.28, 2019, https://doi.org/10.3748/wjg.v25.i28.3753
  23. Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model vol.38, pp.8, 2019, https://doi.org/10.1002/jum.14893
  24. Sinusoidal obstruction syndrome: A systematic review of etiologies, clinical symptoms, and magnetic resonance imaging features vol.7, pp.18, 2019, https://doi.org/10.12998/wjcc.v7.i18.2746
  25. Gynura Segetum Related Hepatic Sinusoidal Obstruction Syndrome: A Liver Disease with High Mortality and Misdiagnosis Rate vol.25, pp.35, 2014, https://doi.org/10.2174/1381612825666191007162024
  26. Noninvasive imaging diagnosis of sinusoidal obstruction syndrome: a pictorial review vol.10, pp.1, 2014, https://doi.org/10.1186/s13244-019-0791-x
  27. Transjugular intrahepatic portosystemic shunt for pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome vol.26, pp.24, 2014, https://doi.org/10.3748/wjg.v26.i24.3472
  28. Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria‐mediated apoptosis vol.40, pp.11, 2014, https://doi.org/10.1002/jat.4004
  29. Clinical characteristics, CT signs, and pathological findings of Pyrrolizidine alkaloids-induced sinusoidal obstructive syndrome: a retrospective study vol.20, pp.None, 2020, https://doi.org/10.1186/s12876-020-1180-0
  30. Successful defibrotide treatment of a patient with veno-occlusive disease after living-donor liver transplantation : A case report vol.100, pp.25, 2021, https://doi.org/10.1097/md.0000000000026463
  31. Hepatic sinusoidal obstruction syndrome caused by the ingestion of Gynura segetum in a patient with alcoholic cirrhosis: a case report vol.49, pp.4, 2014, https://doi.org/10.1177/0300060520980649
  32. Herb-induced liver injury: Systematic review and meta-analysis vol.9, pp.20, 2014, https://doi.org/10.12998/wjcc.v9.i20.5490
  33. Timing and efficacy of transjugular intrahepatic portosystemic shunt in patients with pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome vol.11, pp.1, 2014, https://doi.org/10.1038/s41598-021-01201-w