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HIV 감염 환자에서 피부의 좁쌀결핵으로 발현한 IRIS 1예

Immune Reconstitution Inflammatory Syndrome Presenting as Cutaneous Miliary Tuberculosis in an HIV-Infected Patient

  • 고재훈 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 신범수 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 이성수 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 임경숙 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 이우주 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 유정래 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 강철인 (성균관대학교 의과대학 삼성서울병원 내과)
  • Ko, Jaehoon (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Beomsu (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Seong Soo (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lim, Kyung-Suk (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Woo Joo (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yoo, Jeong Rae (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Cheol-In (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2013.05.21
  • 심사 : 2013.08.22
  • 발행 : 2014.05.01

초록

피부의 좁쌀결핵은 면역저하 상태에서 발생하는 결핵의 드문 감염형태로, 구진 농포성 발진과 피부를 포함한 여러 장기로의 결핵균의 혈행성 다장기 감염을 특징으로 한다. 저자들은 ART를 시작한 HIV 감염 환자에서 피부의 좁쌀결핵으로 발현한 IRIS 첫 예를 경험하여 이를 보고하는 바이다.

Tuberculosis is one of the most common opportunistic diseases in human immunodeficiency virus (HIV)-infected patients in Korea, and extra-pulmonary infections are frequent in these patients. Cutaneous miliary tuberculosis is a rare form of tuberculosis that presents as a papulopustular eruption and hematogenous dissemination of Mycobacterium tuberculosis to multiple organs. This has been reported in patients with progressive HIV infection. We report the first case of cutaneous miliary tuberculosis that developed as a manifestation of immune reconstitution inflammatory syndrome (IRIS) after initiating antiretroviral therapy (ART).

키워드

참고문헌

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피인용 문헌

  1. Mycobacterium avium Complex Infection-Related Immune Reconstitution Inflammatory Syndrome Mimicking Lymphoma in an Human Immunodeficiency Virus-Infected Patient vol.50, pp.4, 2014, https://doi.org/10.3947/ic.2018.50.4.350