The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Multiple Gastrointestinal Tract MALT Lymphomas with Bone Marrow Involvement: A Case Report and Literature Review

골수를 침범한 다발성 위장관 MALT 림프종

  • Kim, Hyung Jun (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Park, Jongha (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Joo, Young-Don (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Lee, Soon Il (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Lee, Eun Ji (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Kim, Hyun Tae (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Kim, Ji Yeon (Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine)
  • 김형준 (인제대학교 해운대백병원 내과) ;
  • 박종하 (인제대학교 해운대백병원 내과) ;
  • 주영돈 (인제대학교 해운대백병원 내과) ;
  • 이순일 (인제대학교 해운대백병원 내과) ;
  • 이은지 (인제대학교 해운대백병원 내과) ;
  • 김현태 (인제대학교 해운대백병원 내과) ;
  • 김지연 (인제대학교 해운대백병원 병리과)
  • Received : 2013.10.01
  • Accepted : 2013.11.18
  • Published : 2014.05.01
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Abstract

The stomach is the most common site of gastrointestinal tract lymphoma, while synchronous mucosa-associated lymphoid tissue (MALT) lymphomas of the stomach and duodenum are very rare. A literature review found no reported case of synchronous gastroduodenal MALT lymphomas with involvement of the bone marrow and spleen. Here, we describe the case of a 62-year-old male who was diagnosed with synchronous MALT lymphomas of the stomach and duodenum based on upper gastrointestinal endoscopy and pathology. Other staging evaluations, including colonoscopy, abdominopelvic and chest computed tomography (CT), $^{18}F$ fludeoxyglucose-positron emission tomography (FDG-PET), and a bone marrow examination, showed involvement of the bone marrow and spleen. We diagnosed stage EIV MALT lymphoma and began systemic chemotherapy. We report the first case of MALT lymphomas arising synchronously in both the stomach and duodenum with bone marrow involvement and review the literature.

위는 위장관 림프종의 75% 이상을 차지하는 가장 흔한 발생 장소이지만 위와 십이지장에서 동시에 발생한 MALT 림프종은 1983년부터 2013년까지 4예밖에 보고되지 않았을 정도로 매우 드물다. 저자들은 위와 십이지장을 침범한 다발성 위장관 MALT 림프종이 골수와 비장을 침범한 증례를 경험하였으며 향후에 다발성 위장관 MALT 림프종의 경우에 골수 생검을 더 적극적으로 해야 할 것을 제안하는 바이다.

Keywords

References

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