대한치매학회지 (Dementia and Neurocognitive Disorders)

대한치매학회 (Korean Dementia Association)
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초로기 치매 증상으로 발현된 후천면역결핍증에서의 진행다초점백질뇌병증 증례

A Case of Progressive Multifocal Leukoencephalopathy in Acquired Immune Deficiency Syndrome Initially Presented with Early Onset Dementia

  • 박평강 (한양대학교 의과대학 신경과학교실) ;
  • 오정근 (한양대학교 의과대학 신경과학교실) ;
  • 고성호 (한양대학교 의과대학 신경과학교실) ;
  • 이규용 (한양대학교 의과대학 신경과학교실) ;
  • 이영주 (한양대학교 의과대학 신경과학교실) ;
  • 최호진 (한양대학교 의과대학 신경과학교실)
  • Park, Pyeong Kang (Department of Neurology, Hanyang University College of Medicine) ;
  • Oh, Jung Geun (Department of Neurology, Hanyang University College of Medicine) ;
  • Koh, Seong-Ho (Department of Neurology, Hanyang University College of Medicine) ;
  • Lee, Kyu-Yong (Department of Neurology, Hanyang University College of Medicine) ;
  • Lee, Young Joo (Department of Neurology, Hanyang University College of Medicine) ;
  • Choi, Hojin (Department of Neurology, Hanyang University College of Medicine)
  • 발행 : 2014.05.31
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초록

Progressive multifocal leukoencephalopathy (PML) is a very rare and often fatal demyelinating disease of central nervous system (CNS), which mostly occurs in patients with immunosuppression such as acquired immunodeficiency syndrome (AIDS) patients, transplant patients and patients receiving chemotherapy. PML usually manifests with acute or subacute neurologic deficit. and its late diagnosis may lead death or significant permanent disability. We report a 33-year old man diagnosed with PML in AIDS, who initially presented with gradual onset of dementia. Most symptoms of PML were progressed rapidly for several months, and characterized by focal neurological symptoms. On the other hand, we were experienced in patients without focal neurological symptoms and ongoing overall cognitive decline slowly. Patients with immunosuppression can be presented in a variety of neurological symptoms, detailed examinations for cognitive functions were needed in early stage of the disease.

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