Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Colonic Leiomyoma in Two Dogs

두 마리의 개에서 결장 평활근종의 증례

  • Jung, Joohyun (Ilsan Animal Medical Center) ;
  • Chae, Woongjoo (Ilsan Animal Medical Center) ;
  • Kwon, Dohyung (Ilsan Animal Medical Center) ;
  • Choi, Mincheol (Veterinary Radiology Department, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • Accepted : 2014.10.13
  • Published : 2014.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

Two dogs were referred with the clinical signs of depression and constipation, respectively. One dog with depression had hypoglycemia on biochemistry. On survey abdominal radiographs, a soft tissue density round mass with calcified spots was identified cranial to the urinary bladder. On ultrasonographs, a solitary oval heterogeneous complex-echoic mass with well-defined margin was found. On surgery, the mass was pedunculated and originated from the colonic wall. The resected mass was confirmed as colonic leiomyoma. The other dog with constipation had normal CBC and biochemistry values. On survey abdominal radiographs, there was a soft tissue density round mass dorsal to the descending colon and rectum. The descending colon was displaced ventrally and narrowed by the mass. On ultrasonographs, a well-defined round heteroechoic mass compressed the colon. The mass was also pedunculated and originated from the colonic wall on surgery and confirmed as colonic leiomyoma. Two dogs recovered without any clinical signs after surgery and showed permanent resolution of the clinical signs, respectively.

두 마리의 개가 각각 다른 임상 증상, 저혈당증과 변비를 주증으로 내원하였다. 복부 방사선 검사에서 연조직 밀도의 크고 둥근 종괴가 하복부에서 관찰되었다. 변비를 주증으로 하는 개에서는 이 종괴로 인한 결장의 직경 감소가 관찰되었다. 복부 초음파 검사에서 이질적 에코의 크고 둥근 종괴가 한계 명료하게 관찰되며, 복강의 주요 장기와 관련이 없을 것으로 생각되었다. 탐색적 개복술에서 종괴는 결장의 장막층에서 유래한 것으로 확인되었고, 쉽게 제거되었다. 조직검사에서 평활근종으로 확인되었고, 두 마리 모두 재발 및 후유증 없이 임상 증상이 개선되었다. 결장 평활근종의 신생물딸림증후군으로 저혈당증이 발생한 증례와 결장 평활근종의 직접적인 압박으로 인한 변비가 발생한 증례를 보고한다.

Keywords

References

  1. Bagley RS, Levy JK, Malarkey DE. Hypoglycemia associated with intra-abdominal leiomyoma and leiomyosarcoma in six dogs. J Am Vet Med Assoc 1996; 208: 69-71.
  2. Battaglia L, Petterino C, Zappulli V, Castagnaro M. Hypoglycaemia as a paraneoplastic syndrome associated with renal adenocarcinoma in a dog. Vet Res Commun 2005; 29: 671-675. https://doi.org/10.1007/s11259-005-3305-x
  3. Beaudry D, Knapp DW, Montgomery T, Sandusky GS, Morrison WB, Nelson RW. Smooth muscle tumors associated with hypoglycemia in four dogs: clinical presentation, treatment, and tumor immunohistochmical staining. J Vet Intern Med 1995; 9: 415-418. https://doi.org/10.1111/j.1939-1676.1995.tb03302.x
  4. Bergman PJ. Paraneoplastic syndromes. In: Withrow and MacEwen's small animal clinical oncology, 5th ed. Philadelphia: Saunders. 2013: 86.
  5. Boari A, Barreca A, Bestetti GE, Minuto F, Venturoli M. Hypoglycemia in a dog with a leiomyoma of the gastric wall producing an insulin-like growth factor II-like peptide. Eur J Endocrinol 1995; 132: 744-750. https://doi.org/10.1530/eje.0.1320744
  6. Cohen M, Post GS, Wright JC. Gastrointestinal leiomyosarcoma in 14 dogs. J Vet Intern Med 2003: 17: 107-110. https://doi.org/10.1111/j.1939-1676.2003.tb01331.x
  7. Frost D, Lasota J, Miettinen M. Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 2003: 40: 42-54. https://doi.org/10.1354/vp.40-1-42
  8. Kerpsack SJ, Birchard SJ. Removal of leiomyomas and other noninvasive masses from the cardiac region of the canine stomach. J Am Anim Hosp Assoc 1994; 30: 500.
  9. Leifer CE, Peterson ME, Matus RE. Hypoglycemia associated with nonislet cell tumor in 13 dogs. J Am Vet Med Assoc 1985; 186: 53-55.
  10. Liptak JM, Forrest, LJ. Soft tissue sarcoma. In: Withrow and MacEwen's small animal clinical oncology. 5th ed. Philadelphia: Saunders. 2013: 359-360.
  11. Myers NC, Pennink DG. Ultrasonographic diagnosis of gastrointestinal smooth muscle tumors in the dogs, Vet Radiol Ultrasound 1994; 35: 391-397. https://doi.org/10.1111/j.1740-8261.1994.tb02059.x
  12. Nicole J. Fernandez, Jason Barton, Tim Spotswood. Hypoglycemia in a dog. Can Vet J 2009: 50: 423-426.
  13. Rossi G, Errico G, Perez P, Rossi G, Paltrinieri S. Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor II producing mammary carcinoma. Vet Clin Pathol 2010; 39: 480-484. https://doi.org/10.1111/j.1939-165X.2010.00260.x
  14. Snead EC. A case of bilateral renal lymphosarcoma with secondary polycythaemia and paraneoplastic syndromes of hypoglycaemia and uveitis in an English Springer Spaniel. Vet Comp Oncol 2005; 3: 139-144. https://doi.org/10.1111/j.1476-5810.2005.00069.x
  15. Weller RE. Paraneoplastic disorders in dogs with hematopoietic tumors. Vet Clin North Am Small Anim Pract 1985: 15: 805-816. https://doi.org/10.1016/S0195-5616(85)50037-6
  16. Willard MD. Alimentary neoplasia in geriatric dogs and cats. Vet Clin North Am Small Anim Pract 2012; 42: 693-706. https://doi.org/10.1016/j.cvsm.2012.04.006
  17. Zapf J. Role of insulin-like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumor hypoglycemia. J Intern Med 1993; 234: 543-552. https://doi.org/10.1111/j.1365-2796.1993.tb01012.x
  18. Zini E, Glaus TM, Minuto F, Arvigo M, Hauser B, Reusch CE. Paraneoplastic hypoglycemia due to an insulin-like growth factor type-II secreting hepatocellular carcinoma in a dog. J Vet Intern Med 2007; 21: 193-195. https://doi.org/10.1111/j.1939-1676.2007.tb02946.x