Parasites, Hosts and Diseases

  • 제52권5호
  • /
  • Pages.557-564
  • /
  • 2014
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지
DOI QR코드

DOI QR Code

Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations

  • 투고 : 2014.01.16
  • 심사 : 2014.05.20
  • 발행 : 2014.10.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.

키워드

참고문헌

  1. Singh V, Mishra N, Awasthi G, Dash AP, Das A. Why is it important to study malaria epidemiology in India? Trends Parasitol 2009; 25: 452-457. https://doi.org/10.1016/j.pt.2009.06.004
  2. Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 2008; 455: 757-763. https://doi.org/10.1038/nature07327
  3. Picot S, Bienvenu AL. Plasmodium vivax infection: not so benign. Med Sci (Paris) 2009; 25: 622-626. https://doi.org/10.1051/medsci/2009256-7622
  4. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, Kochar A, Khatri MP, Gupta V. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 2009; 80: 194-198.
  5. Tjitra E, Anstey NM, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN. Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med 2008; 5: e128. https://doi.org/10.1371/journal.pmed.0050128
  6. Lacerda MV, Fragoso SC, Alecrim MG, Alexandre MA, Magalhaes BM, Siqueira AM, Ferreira LC, Araujo JR, Mourao MP, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C, del Portillo H, Ordi J, Alonso PL, Bassat Q. Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: To what extent does this parasite kill? Clin Infect Dis 2012; 55: e67-e74. https://doi.org/10.1093/cid/cis615
  7. Fernandez-Becerra C, Yamamoto MM, Vencio RZ, Lacerda M, Rosanas-Urgell A, del Portillo HA. Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily. Trends Parasitol 2009; 25: 44-51. https://doi.org/10.1016/j.pt.2008.09.012
  8. Lopez FJ, Bernabeu M, Fernandez-Becerra C, del Portillo HA. A new computational approach redefines the subtelomeric vir superfamily of Plasmodium vivax. BMC Genomics 2013; 14: 8. https://doi.org/10.1186/1471-2164-14-8
  9. Bernabeu M, Lopez FJ, Ferrer M, Martin-Jaular L, Razaname A, Corradin G, Maier AG, del Portillo HA, Fernandez-Becerra C. Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor. Cell Microbiol 2012; 14: 386-400. https://doi.org/10.1111/j.1462-5822.2011.01726.x
  10. Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araujo MO, Russell B, Suwanarusk R, Snounou G, Renia L, Costa FT. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis 2010; 202: 638-647. https://doi.org/10.1086/654815
  11. Gupta B, Srivastava N, Das A. Inferring the evolutionary history of Indian Plasmodium vivax from population genetic analyses of multilocus nuclear DNA fragments. Mol Ecol 2012; 21: 1597-1616. https://doi.org/10.1111/j.1365-294X.2012.05480.x
  12. Gupta P, Das A, Singh OP, Ghosh SK, Singh V. Assessing the genetic diversity of the vir genes in Indian Plasmodium vivax population. Acta Trop 2012; 124: 133-139. https://doi.org/10.1016/j.actatropica.2012.07.002
  13. Gupta B, Gupta P, Sharma A, Singh V, Dash AP, Das A. High proportion of mixed-species Plasmodium infections in India revealed by PCR diagnostic assay. Trop Med Int Health 2010; 15: 819-824. https://doi.org/10.1111/j.1365-3156.2010.02549.x
  14. del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B, Lanzer M. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 2001; 410: 839-842. https://doi.org/10.1038/35071118
  15. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance and maximum parsimony methods. Mol Biol Evol 2011; 28: 2731-2739. https://doi.org/10.1093/molbev/msr121
  16. Librado P, Rozas J. DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. Bioinformatics 2009; 25: 1451-1452. https://doi.org/10.1093/bioinformatics/btp187
  17. Nei M. Molecular evolutionary genetics. Columbia University Press, USA. 1987.
  18. Tajima F. Evolutionary relationship of DNA sequences in finite populations. Genetics 1983; 105: 437-460.
  19. Watterson GA. On the number of segregating sites in genetical models without recombination. Theor Popul Biol 1975; 7: 256-276. https://doi.org/10.1016/0040-5809(75)90020-9
  20. Tajima F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 1989; 123: 585-595.
  21. Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2004; 2: e286. https://doi.org/10.1371/journal.pbio.0020286
  22. Peakall R, Smouse PE. GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research- an update. Bioinformatics 2012; 28: 2537-2539. https://doi.org/10.1093/bioinformatics/bts460
  23. Merino EF, Fernandez-Becerra C, Durham AM, Ferreira JE, Tumilasci VF, d'Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi T, Udagama-Randeniya P, Handunnetti SM, del Portillo HA. Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Mol Biochem Parasitol 2006; 149: 10-16. https://doi.org/10.1016/j.molbiopara.2006.04.002
  24. Chenet SM, Tapia LL, Escalante AA, Durand S, Lucas C, Bacon DJ. Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax. Malar J 2012; 11: 68. https://doi.org/10.1186/1475-2875-11-68
  25. Prajapati SK, Joshi H, Valecha N. Plasmodium vivax merozoite surface protein-3${\alpha}$: a high resolution marker for genetic diversity studies. J Vector Borne Dis 2010; 47: 85-90.

피인용 문헌

  1. Plasmodium vivax msp - 3α polymorphisms: analysis in the Indian subcontinent vol.15, pp.None, 2014, https://doi.org/10.1186/s12936-016-1524-y
  2. Diversity of vir Genes in Plasmodium vivax from Endemic Regions in the Republic of Korea: an Initial Evaluation vol.55, pp.2, 2017, https://doi.org/10.3347/kjp.2017.55.2.149