Maxillofacial Plastic and Reconstructive Surgery

  • 제36권5호
  • /
  • Pages.192-200
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  • 2014
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  • 2288-8101(pISSN)
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  • 2288-8586(eISSN)
대한악안면성형재건외과학회 (Korean Association of Maxillofacial Plastic and Reconstructive Surgeons)
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Soft Tissue Augmentation with Silk Composite Graft

  • Park, Yong-Tae (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kweon, Hae Yong (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • 투고 : 2014.07.29
  • 심사 : 2014.09.03
  • 발행 : 2014.09.30
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초록

Purpose: The objective of this study was to evaluate the interaction between 4-hexylresorcinol (4HR) and antibody as that affects the performance of a silk-4HR combination graft for soft tissue augmentation in an animal model. Methods: The silk graft materials consisted of four types: silk+10% tricalcium phosphate (TCP) (ST0), silk+10% TCP+1% 4HR (ST1), silk+10% TCP+3% 4HR (ST3), and silk+10% TCP+6% 4-HR (ST6). The antibody binding assay tested the 4HR effect and scanning electron microscopic (SEM) exam was done for silk grafts. The animal experiment used a subcutaneous pocket mouse model. The graft - SH0 or SH1 or SH3 or SH6 - was placed in a subcutaneous pocket. The animals were killed at one, two, and four weeks, postoperatively. The specimens were subjected to histological analysis and lysozyme assay. Results: Groups with 4HR applied showed lower antibody binding affinity to antigen compared to groups without 4HR. In the SEM examination, there was no significant difference among groups. Histological examinations revealed many foreign body giant cells in ST0 and ST1 group at four weeks postoperatively. Both ST3 and ST6 groups developed significantly lower levels of giant cell values compared to ST0 and ST1 groups (P < 0.001) at four weeks postoperatively. In the lysozyme assay, the ST1 and ST3 groups showed denser signals than the other groups. Conclusion: 4HR combined silk implants resulted in high levels of vascular and connective tissue regeneration.

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참고문헌

  1. Kreutzer C, von Gregory HF, Fischer H. Skin-fat-graft: a simple tool for reconstruction of small deep defects of the nose. Facial Plast Surg 2014;30:247-59. https://doi.org/10.1055/s-0034-1376870
  2. Zhou W, He M, Liao Y, Yao Z. Reconstructing a complex central facial defect with a multiple-folding radial forearm flap. J Oral Maxillofac Surg 2014;72:836.e1-4. https://doi.org/10.1016/j.joms.2013.12.027
  3. Marbacher S, Andereggen L, Fandino J, Lukes A. Combined bone and soft-tissue augmentation surgery in temporo-orbital contour reconstruction. J Craniofac Surg 2011;22:266-8. https://doi.org/10.1097/SCS.0b013e3181f7b781
  4. Kerem H, Bali U, Sonmez E, Manavbasi YI, Yoleri L. The cranially based contralateral nasolabial flap for reconstruction of paranasal and periorbital surgical defects. J Plast Reconstr Aesthet Surg 2014;67:655-61. https://doi.org/10.1016/j.bjps.2014.01.027
  5. Baek R, Heo C, Kim BK. Use of various free flaps in progressive hemifacial atrophy. J Craniofac Surg 2011;22:2268-71. https://doi.org/10.1097/SCS.0b013e318232784a
  6. Winstead JM, Olson GT, Frodel JL. Reconstruction of periparotid defects using temporoparietal fascia flap with layered acellular human dermal allograft. Craniomaxillofac Trauma Reconstr 2012;5:19-24. https://doi.org/10.1055/s-0031-1300959
  7. Peeters WJ, Nanhekhan L, Van Ongeval C, Fabre G, Vandevoort M. Fat necrosis in deep inferior epigastric perforator flaps: an ultrasound-based review of 202 cases. Plast Reconstr Surg 2009;124:1754-8. https://doi.org/10.1097/PRS.0b013e3181bf7e03
  8. Miller JJ, Popp JC. Fat hypertrophy after autologous fat transfer. Ophthal Plast Reconstr Surg 2002;18:228-31. https://doi.org/10.1097/00002341-200205000-00015
  9. Brown C, Watson D. Lip augmentation utilizing allogenic acellular dermal graft. Facial Plast Surg 2011;27:550-4. https://doi.org/10.1055/s-0031-1298780
  10. Hunter B, Hopkins C, Tharavaj S, Roberts D. Permacol in augmentation rhinoplasty. Clin Otolaryngol 2010;35:340-1. https://doi.org/10.1111/j.1749-4486.2010.02156.x
  11. Fan KL, Yim E, Salgado CJ, Romanelli P. Surgical treatment of Papillon-Lefevre Syndrome with bovine collagen and skin graft. J Plast Reconstr Aesthet Surg 2013;66:e392-3. https://doi.org/10.1016/j.bjps.2013.07.032
  12. Sakai K, Hamaguchi T, Noguchi-Shinohara M, et al. Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ Open 2013;3:e003400. https://doi.org/10.1136/bmjopen-2013-003400
  13. Moura LI, Dias AM, Suesca E, et al. Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Biochim Biophys Acta 2014;1842:32-43. https://doi.org/10.1016/j.bbadis.2013.10.009
  14. Seok H, Park YT, Kim SG, Jin HJ. The effect of silk fibroin particles coated with hydroxyapatites on bone regeneration in the rat calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 2013;35:13-7. https://doi.org/10.14402/jkamprs.2013.35.1.013
  15. Kim MK, Yoo KY, Kwon KJ, et al. Powdered wound dressing materials made from wild silkworm Antheraea pernyi silk fibroin on full-skin thickness burn wounds on rats. Maxillofac Plast Reconstr Surg 2014;36:111-5. https://doi.org/10.14402/jkamprs.2014.36.3.111
  16. Lee OJ, Lee JM, Kim JH, et al. Biodegradation behavior of silk fibroin membranes in repairing tympanic membrane perforations. J Biomed Mater Res A 2012;100:2018-26.
  17. Lee SW, Park YT, Kim SG, Kweon HY, Jo YY, Lee HS. The effects of tetracycline-loaded silk fibroin membrane on guided bone regeneration in a rabbit calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 2012;34:293-8.
  18. Park KY, Choi KH, Park YJ, et al. Silk fibroin and substance P combination graft for the reconstruction of a bone defect. J Korean Assoc Maxillofac Plast Reconstr Surg 2011;33:293-300.
  19. Park YT, Kwon KJ, Park YW, et al. The effect of silk fibroin/ nano-hydroxyapatite/corn starch composite porous scaffold on bone regeneration in the rabbit calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 2011;33:459-66.
  20. Park YT, Park SY, Kim MK, Kim SG, Park YW, Kwon KJ. Effect of 4-hexylresorcinol on blood coagulation and healing of injured vessel in a rat model. J Korean Assoc Maxillofac Plast Reconstr Surg 2013;35:284-93. https://doi.org/10.14402/jkamprs.2013.35.5.284
  21. Evans RT, Baker PJ, Coburn RA, Fischman SL, Genco RJ. In vitro antiplaque effects of antiseptic phenols. J Periodontol 1977;48:156-62. https://doi.org/10.1902/jop.1977.48.3.156
  22. Rojas-Grau MA, Soliva-Fortuny R, Niartin-Belloso O. Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid. J Food Sci 2008;73:S267-72. https://doi.org/10.1111/j.1750-3841.2008.00794.x
  23. Kim SG, Lee SW, Park YW, Jeong JH, Choi JY. 4-hexylresorcinol inhibits $NF-{\kappa}B$ phosphorylation and has a synergistic effect with cisplatin in KB cells. Oncol Rep 2011;26:1527-32.
  24. Kim MK, Park YT, Kim SG, Park YW, Lee SK, Choi WS. The effect of a hydroxyapatite and 4-hexylresorcinol combination graft on bone regeneration in the rabbit calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 2012;34:377-83.
  25. Kweon H, Kim SG, Choi JY. Inhibition of foreign body giant cell formation by 4- hexylresorcinol through suppression of diacylglycerol kinase delta gene expression. Biomaterials 2014;35:8576-84. https://doi.org/10.1016/j.biomaterials.2014.06.050
  26. Deryabin DG, Mikhailenko-(Romanenko) NA, El'-Registan GI. The effect of alkylhydroxybenzenes on the antigen-binding capacity of antibodies. Microbiology 2009;78:569-74 . https://doi.org/10.1134/S0026261709050063
  27. Peer LA. Loss of weight and volume in human fat grafts: with postulation of a "cell survival theory". Plast Reconstr Surg 1950;5:217-30. https://doi.org/10.1097/00006534-195003000-00002
  28. Chajchir A, Benzaquen I, Wexler E, Arellano A. Fat injection. Aesthetic Plast Surg 1990;14:127-36. https://doi.org/10.1007/BF01578338
  29. Tatakis DN, Promsudthi A, Wikesjo UM. Devices for periodontal regeneration. Periodontol 2000 1999;19:59-73. https://doi.org/10.1111/j.1600-0757.1999.tb00147.x
  30. Cao Y, Wang B. Biodegradation of silk biomaterials. Int J Mol Sci 2009;10:1514-24. https://doi.org/10.3390/ijms10041514
  31. Musto JD, Sane JN, Warner VD. Quantitative determination of hexylresorcinol in commercial antiseptic solution by high-pressure liquid chromatography. J Pharm Sci 1979;68:240-1. https://doi.org/10.1002/jps.2600680232
  32. Buchholz V, Leuwer M, Ahrens J, Foadi N, Krampfl K, Haeseler G. Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner. Naunyn Schmiedebergs Arch Pharmacol 2009;380:161-8. https://doi.org/10.1007/s00210-009-0416-x
  33. Etienne O, Schneider A, Kluge JA, et al. Soft tissue augmentation using silk gels: an in vitro and in vivo study. J Periodontol 2009;80:1852-8. https://doi.org/10.1902/jop.2009.090231

피인용 문헌

  1. Comparison of unprocessed silk cocoon and silk cocoon middle layer membranes for guided bone regeneration vol.38, pp.1, 2016, https://doi.org/10.1186/s40902-016-0057-1
  2. Botulinum Toxin Conjugated With Silk Fibroin and 4-Hexylresorcinol vol.28, pp.4, 2017, https://doi.org/10.1097/SCS.0000000000003763
  3. Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol vol.7, pp.2045-2322, 2017, https://doi.org/10.1038/srep42441
  4. Effects of 4-Hexylresorcinol on Protein Expressions in RAW 264.7 Cells as Determined by Immunoprecipitation High Performance Liquid Chromatography vol.9, pp.None, 2014, https://doi.org/10.1038/s41598-019-38946-4