Childhood Cancer Incidence and Survival 1985-2009, Khon Kaen, Thailand

  • Wiangnon, Surapon (Department of Pediatrics, Faculty of Medicine, Khon Kaen University) ;
  • Jetsrisuparb, Arunee (Department of Pediatrics, Faculty of Medicine, Khon Kaen University) ;
  • Komvilaisak, Patcharee (Department of Pediatrics, Faculty of Medicine, Khon Kaen University) ;
  • Suwanrungruang, Krittika (Khon Kaen Province Cancer Registry, Cancer Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University)
  • 발행 : 2014.10.11


Background: The Khon Kaen Cancer Registry (KKCR) was established in 1984. Previous population-based incidences and survivals of childhood cancer in Thailand were determined using a short cancer registration period. Materials and Methods: Data were retrieved of all children residing in Khon Kaen, between 0-15 years, diagnosed as having cancer and registered in the KKCR (1985-2009). The follow-up censored date was December 31, 2012. The childhood cancers were classified into 12 diagnostic groups, according to the International Classification of Childhood Cancer. The incidence was calculated by the standard method. Survival of childhood cancer was investigated using the KKCR population-based registration data and overall survival calculated using the Kaplan Meier method. Results: In the study period, 912 newly diagnosed cases of childhood cancer were registered. The respective mean and median age was 6.4 (SD=4.6) and 6 (0-14) years. The age-peak for incidence was 0-4 years. The age-standardized rate (ASR) was 83 per million. Leukemia was the most common cancer (N=360, ASR 33.8) followed by neoplasms of the central nervous system (CNS, N=150, ASR 12.8) and lymphoma (N=79, ASR 7.0). The follow-up duration totaled 101,250 months. The death rate was 1.11 per 100 person-months (95%CI: 1.02 -1.20). The 5-year overall survival was 52% (95%CI: 53-56.9) for all cancers. The respective 5-year overall survival for (1) acute lymphoblastic leukemia (ALL), (2) acute non-lymphoblastic leukemia (ANLL), (3) lymphoma, (4) germ cell tumors, (5) renal tumors, (6) retinoblastoma, (7) soft tissue tumors, (8) CNS tumors, (9) bone tumors, (10) liver tumors, and (11) neuroblastoma was (1) 51%, (2) 37%, (3) 63%, (4) 74%, (5) 67%, (6) 55%, (7) 46%, (8) 44%, (9) 36%, (10) 34%, and (11) 25%. Conclusions: The incidence of childhood cancer is lower than those of western countries. Respective overall survival for ALL, lymphoma, renal tumors, liver tumors, retinoblastoma, soft tissue tumors is lower than that reported in developed countries while survival for CNS tumors, neuroblastoma and germ cell tumors is comparable.


  1. Ajiki W, Tsukuma H, Oshima A (2004). Survival rates of childhood cancer patients in Osaka, Japan. Jpn J Clin Oncol, 34, 50-4.
  2. Gatta G, Capocaccia R, Stiller C, et al (2005). Childhood cancer survival trends in Europe: A EUROCARE Working group study. J Clin Oncol, 23, 3742-51.
  3. Jensen OM, Parkin DM, Maclennan R, Muir CS, Skeet RG, Eds (1991). Cancer registration: Principles and Method. IARC Scientific Publications No.95, Lyon: International Agency for Research on Cancer. 159-76.
  4. Kamsa-ard S, Wiangnon S, Suwanrungruang K, et al (2004). Khon Kaen cancer registry: survival of childhood malignancies recorded between 1993-1997. Thai J Pediatr, 43, 25-31.
  5. Kramarova E, Stiller CA, Ferlay J, Parkin DM, et al (1996). The international classification of childhood cancer. Int J Cancer, 68, 759-65.<759::AID-IJC12>3.0.CO;2-W
  6. National Statistic Office. Statistical data bank and information dissemination division (2003). The 2000 population and housing census. Office of prime minister.
  7. Pakakasama S, Veerakul G, Sosotthikul D, et al (2010). Late effects in survivors of childhood acute lymphoblastic leukemia: a study from Thai Pediatric Oncology Group. Int J Hematol, 91, 850-4.
  8. Parkin DM, Kramarova E, Draper GJ, et al (1998). International incidence of childhood cancer. Vol II. IARC scientific publication, 144.
  9. Redner A (2011). Leukemias. In: Manual of pediatric hematology and oncology. Lanzkowsky P. 5th ed. Elsevier, Amsterdam. p, 518-66.
  10. Ries LAG, Smith MA, Gurney JG, et al (eds) (1999). Cancer incidence and survival among children and adolescents:United States SEER program 1975-1995, National cancer institute, SEER program. NIH Pub, 99-4649. Bethesda, MD.
  11. Seksarn P (2011). Outcome of childhood leukemia, ThaiPOG study. St. Jude-VIVA forum in pediatric oncology, Singapore.
  12. Sriamporn S, Vattanasapt V, Martin N, et al (1996). Incidence of childhood cancer in Thailand 1988-1991. Paediatr Perinat Epidemiol, 10, 73-85.
  13. Sutra S, Chirawatkul A, Bundhamcharoen K, Ekachampaka P, Wattanamano N (2009). Cause of death analysis by age group. In: Child and adolescent health situation 2009. Working group for child and adolescent health situation in Thailand. The Royal College of Pediatricians of Thailand. Beyond Enterprise, 17-88.
  14. Thai Pediatric Oncology Group (2014). National protocol for treatment of childhood cancer 2014. Bangkok, M Print Corporation.
  15. Vatanasapt V (1999). Childhood cancer. In: Cancer in Thailand 1992-1994. Deerasamee S, Martin N, Sriplung H, et al. eds; IARC No 34, Lyon, 81-6.
  16. Wiangnon S, Kamsa-ard S, Jetsrisuparb A, et al (2003). Childhood cancer in Thailand 1995-1997. Asian Pac J Cancer Prev, 4, 237-43.
  17. Wiangnon S, Kamsa-ard S, Jetsrisuparb A, et al (2004). Childhood malignancies at Khon Kaen, Thailand: population-based cancer registry. Thai J Pediatr, 43, 38-43.
  18. Wiangnon S, Veerakul G, Nuchprayoon I, et al (2011). Childhood cancer incidence and survival 2003-5, Thailand: study from the Thai Pediatric Oncology Group. Asian Pac J Cancer Prev, 12, 2215-20.
  19. World Health Organization (2000). In: International classification of diseases for oncology. Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin DM, Whelan S, eds. 3rd ed. Geneva.

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