References
- Adams JM, Cory S (2007). The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 26, 1324-37. https://doi.org/10.1038/sj.onc.1210220
- Allen RT, Hunter WJ, 3rd, Agrawal DK (1997). Morphological and biochemical characterization and analysis of apoptosis. J Pharmacol Toxicol Methods, 37, 215-28. https://doi.org/10.1016/S1056-8719(97)00033-6
- Attele AS, Zhou YP, Xie JT, et al (2002). Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes, 51, 1851-8. https://doi.org/10.2337/diabetes.51.6.1851
- Bomfim DS, Ferraz RP, Carvalho NC, et al (2013). Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells. Basic Clin Pharmacol Toxicol, 113, 300-6.
- Chen G, Yang X, Nong S, et al (2013). Two novel hydroperoxylated products of 20 (S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells. Biotechnol Lett, 35, 439-43. https://doi.org/10.1007/s10529-012-1098-x
- Colditz GA, Bohlke K (2014). Priorities for the primary prevention of breast cancer. CA Cancer J Clin, 64, 186-94. https://doi.org/10.3322/caac.21225
- Florescu A, Amir E, Bouganim N, et al (2011). Immune therapy for breast cancer in 2010-hype or hope? Curr Oncol, 18, 9-18.
- Gao JL, Lv GY, He BC, et al (2013). Ginseng saponin metabolite 20 (S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol Rep, 30, 292-8.
- Hail N, Jr., Carter BZ, Konopleva M, et al (2006). Apoptosis effector mechanisms: a requiem performed in different keys. Apoptosis, 11, 889-904. https://doi.org/10.1007/s10495-006-6712-8
- Lin G, Yu X, Wang J, et al (2013). Beneficial effects of 20 (S)-protopanaxadiol on antitumor activity and toxicity of cyclophosphamide in tumor-bearing mice. Exp Ther Med, 5, 443-7.
- Liu GY, Bu X, Yan H, et al (2007). 20S-protopanaxadiolinduced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod, 70, 259-64. https://doi.org/10.1021/np060313t
- Ly JD, Grubb DR, Lawen A (2003). The mitochondrial membrane potential (deltapsi (m)) in apoptosis; an update. Apoptosis, 8, 115-28. https://doi.org/10.1023/A:1022945107762
- Ma WD, Zou YP, Wang P, et al (2014). Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 70, 1-8. https://doi.org/10.1016/j.fct.2014.04.014
- Matin MM, Nakhaeizadeh H, Bahrami AR, et al (2014). Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina. Asian Pac J Cancer Prev, 15, 2123-8. https://doi.org/10.7314/APJCP.2014.15.5.2123
- Newman DJ, Cragg GM (2012). Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod, 75, 311-35. https://doi.org/10.1021/np200906s
- Oh SH, Lee BH (2004). A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol, 194, 221-9. https://doi.org/10.1016/j.taap.2003.09.011
- Quan HY, Yuan HD, Jung MS, et al (2012). Ginsenoside Re lowers blood glucose and lipid levels via activation of AMPactivated protein kinase in HepG2 cells and high-fat diet fed mice. Int J Mol Med, 29, 73-80.
- Shin JY, Song JY, Yun YS, et al (2002). Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol Immunotoxicol, 24, 469-82. https://doi.org/10.1081/IPH-120014730
- Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63, 11-30. https://doi.org/10.3322/caac.21166
- Singh DV, Agarwal S, Singh P, et al (2013). Curcumin conjugates induce apoptosis via a mitochondrion dependent pathway in MCF-7 and MDA-MB-231 cell lines. Asian Pac J Cancer Prev, 14, 5797-804. https://doi.org/10.7314/APJCP.2013.14.10.5797
- Wang CZ, Calway T, Yuan CS (2012). Herbal medicines as adjuvants for cancer therapeutics. Am J Chin Med, 40, 657-69. https://doi.org/10.1142/S0192415X12500498
- Wang LC, Lee TF (2000). Effect of ginseng saponins on cold tolerance in young and elderly rats. Planta Med, 66, 144-7. https://doi.org/10.1055/s-2000-11122
- Wang W, Rayburn ER, Hao M, et al (2008). Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate, 68, 809-19. https://doi.org/10.1002/pros.20742
- Xie JT, Wang CZ, Zhang B, et al (2009). In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull, 32, 1552-8. https://doi.org/10.1248/bpb.32.1552
- Xu C, Teng J, Chen W, et al (2010a). 20 (S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Prog Neuropsychopharmacol Biol Psychiatry, 34, 1402-11. https://doi.org/10.1016/j.pnpbp.2010.07.010
- Xu HL, Yu XF, Qu SC, et al (2010b). Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur J Pharmacol, 645, 14-22. https://doi.org/10.1016/j.ejphar.2010.06.072
- Yu Y, Zhou Q, Hang Y, et al (2007). Antiestrogenic effect of 20S-protopanaxadiol and its synergy with tamoxifen on breast cancer cells. Cancer, 109, 2374-82. https://doi.org/10.1002/cncr.22659
- Zhang D, Yasuda T, Yu Y, et al (1996). Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation. Free Radic Biol Med, 20, 145-50. https://doi.org/10.1016/0891-5849(95)02020-9
- Zhang R, Chung Y, Kim HS, et al (2013a). 20-O- (beta-Dglucopyranosyl)-20 (S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells. Oncol Rep, 29, 1365-70.
- Zhang YL, Zhang R, Xu HL, et al (2013b). 20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway. Am J Chin Med, 41, 1137-52. https://doi.org/10.1142/S0192415X13500778
- Zhou J, Luo YH, Wang JR, et al (2013). Gambogenic acid induction of apoptosis in a breast cancer cell line. Asian Pac J Cancer Prev, 14, 7601-5. https://doi.org/10.7314/APJCP.2013.14.12.7601
- Zhu S, Yao F, Li WH, et al (2013). PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. Asian Pac J Cancer Prev, 14, 5687-92. https://doi.org/10.7314/APJCP.2013.14.10.5687
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