AIDS-Related Non-Hodgkin Lymphoma: Imaging Feature Analysis of 27 Cases and Correlation with Pathologic Findings

  • Yang, Jun (Department of Radiology, Beijing Friendship Hospital, Capital Medical University) ;
  • Wang, Peng (Department of Pathology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Lv, Zhi-Bin (Department of Radiology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Wei, Lian-Gui (Department of Radiology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Xu, Yun-Liang (Department of Radiology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Zhou, An (Department of Radiology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Xu, Dong-Hai (Department of Radiology, Beijing Ditan Hospital, Institute of Infectious Diseases, Capital Medical University) ;
  • Ma, Da-Qing (Department of Radiology, Beijing Friendship Hospital, Capital Medical University)
  • 발행 : 2014.10.11


Background: Some tumor types are related to HIV, including non-Hodgkin lymphoma (NHL). The morbidity and mortality of NHL has remained high, even after highly active antiretroviral therapy (HAART) was introduced. We collected cases of AIDS with NHL, and evaluated the imaging features and strategies for diagnosis. Materials and Methods: There were 27 patients with AIDS and tumors confirmed by pathology. There were 9 patients with Burkitt lymphoma, 16 with diffuse large B cell lymphomas (DLBCLs), and 2 with primary central nervous system (PCNS) lymphomas. All of the patients underwent a series of imaging studies. Three radiologists analyzed the images, and any disagreement was discussed until consensus was reached. Results: The radiologic manifestations of AIDS with NHL were mainly masses and lymphadenopathy, 3 patients having one mass and 12 two or more masses. 7 patients had lymphadenopathy in one site and 3patients had lymphadenopathy in two or more sites. Coarse mucosal folds, thickening of the gastrointestinal wall, and lumen narrowing were typical manifestations of NHL within the gastrointestinal tract. There were 4 patients with masses and 5 with lymphadenopathy inthe 9 with Burkitt lymphoma, and 11 patients with masses 5 with lymphadenopathy in the 16 with DLBCLs. Conclusion: NHL is a malignancy that usually occurs in patients with AIDS. Imaging is an important method by which to evaluate lesions, masses, and lymphadenopathy. Fine needle aspiration biopsy and stereotaxis biopsy are useful methods by which to diagnose NHL.


  1. Beaudrap PD, Boulle C, Lewden C, et al (2013) Morbidity After Antiretroviral Therapy Initiation in HIV-1-Infected Children in West Africa: Temporal Trends and Relation to CD4 Count. Ped Infect Dis J, 32, 354-60.
  2. Busi Rizzi E, Schinina V, Cristofaro M, et al (2001). Non-Hodgkin's lymphoma of the liver in patients with AIDS: sonographic, CT, and MRI findings. J Clin Ultrasound, 29, 125-9.<125::AID-JCU1011>3.0.CO;2-Y
  3. Brimo F, Michel RP, Khetani K, et al (2007). Primary effusion lymphoma: a series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis. Cancer, 111, 224-33.
  4. Carbone A, Cesarman E, Gloghini A, et al (2010). Understanding pathogenetic aspects and clinical presentation of primary effusion lymphoma through its derived cell lines. AIDS, 24, 479-90.
  5. Cappell MS, Botros N (1994). Predominantly gastrointestinal symptoms and signs in 11 consecutive AIDS patients with gastrointestinal lymphoma: a multicenter, multiyear study including 763 HIV-seropositive patients. Am J Gastroenterol, 89, 545-9.
  6. Chun C, Lanfang X, Donald A, et al (2010). Survival of non-Hodgkin lymphoma patients with and without HIV infection in the era of combined antiretroviral therapy. AIDS, 24, 1765-70.
  7. Carbone A, Gloghini A (2005). AIDS-related lymphomas: from pathogenesis to pathology. British Journal of Haematology, 130, 662-70.
  8. Corti M, Villafane MF, Trione N, et al (2005). Primary pulmonary AIDS-related lymphoma. Rev Inst Med Trop, 47, 231-4.
  9. Davison JM, Subramaniam RM, Surasi DS, et al (2011). FDG PET/CT in patients with HIV. AJR, 197, 284-94.
  10. Doweiko J, Dezube BJ, Pantanowitz L (2004). Unusual sites of Hodgkin's lymphoma: CASE 1. HIV-associated Hodgkin's lymphoma of the stomach. J Clin Oncol, 22, 4227-8.
  11. Evans WC, Gilmore D, English J (2011). The role of PET and PET-CT in managing the care of lymphoma patients. J Nucl Med Technol, 39,190-4.
  12. Khan F, Bauer F, Gazi G, et al (2006). Regression of large B-cell non-Hodgkin's lymphoma of stomach with HAART: case report and review. Leuk Lymphoma, 47, 750-4.
  13. Kalogeropoulos IV, Chalazonitis AN, Tsolaki S, et al (2009). A case of primary isolated non-Hodgkin's lymphoma of the esophagus in an immunocompetent patient. World J Gastroenterol, 15, 1901-3.
  14. Latta S, Myint ZW, Jallad B (2010). Primary central nervous system T-cell lymphoma in AIDS patients case report and literature review. Current Oncology, 17, 63-6.
  15. Liu Y (2012). Concurrent FDG avid nasopharyngeal lesion and generalized lymphadenopathy on PET-CT imaging is indicative of lymphoma in patients with HIV infection. AIDS Research Treatment. ???
  16. Li HJ, Cheng JL (2011). AIDS complicated with intestinal lymphoma X-ray radiology, CT scan and pathological findings. Chinese Medical Journal, 124, 1427-30.
  17. Mani D, Guinee D, Aboulafia D (2008). AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma. World J Gastroenterol, 14, 4395-9.
  18. Marcelo C, Maria F. Villafane F, et al (2006). Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus. Braz J Infect Dis, 10, 403-5.
  19. Mendes Luz P, Bruyand M, Ribeiro S, et al (2014). AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies. BMC Infect Dis, 14, 278-82.
  20. Munn S (2002). Imaging HIV/AIDS. Burkitt's lymphoma. AIDS Patient Care STDS, 16, 395-9.
  21. Milling DL, Lazarchick J, Chaudhary UB (2005). Primary mediastinal large B-cell lymphoma in an HIV-infected patient. Am J Med Sci, 329, 136-8.
  22. Mohan H, Bal A, Garg S, et al (2007). Cytomegalovirusassociated pseudotumor simulating gastric malignancy in acquired immunodeficiency syndrome: a case report with review of literature. Jpn J Infect Dis, 60, 134-6.
  23. Polesel J, Clifford GM, Rickenbach M, et al (2008). Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy. AIDS, 22, 301-6.
  24. Ramanathan A, Mahmoud HRR, Hui LP, et al (2014). Oral extranodal non Hodgkin's lymphoma: series of forty two cases in Malaysia, Asian Pac J Cancer Prev, 15, 1633-37.
  25. Rich JD, Crawford JM, Kazanjian SN, et al (1992). Discrete gastrointestinal mass lesions caused by cytomegalovirus in patients with AIDS: report of three cases and review. Clin Infect Dis, 15, 609-14.
  26. Rezende REF, Mantelmacher M, Ferreira SDC, et al (2009). Clinical, endoscopic and prognostic aspects of primary gastric non-Hodgkin's lymphoma associated with acquired immunodeficiency syndrome. Braz J Infect Dis, 13, 2-4.
  27. Senocak E, Oguz KK, Ozgen B, et al (2010). Imaging features of CNS involvement in AIDS. Diagn Interv Radiol, 16, 193-200.
  28. Zacharia TT, Law M, Naidich TP, et al (2008). Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopy. J Neuroimaging, 18, 411-7.

피인용 문헌

  1. Primary mediastinal large B cell lymphoma in a woman who is human immunodeficiency virus positive presenting with superior vena cava syndrome: a case report vol.11, pp.1, 2017,
  2. HIV-related Malignancies and Mimics: Imaging Findings and Management pp.1527-1323, 2018,