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GSTM1 Polymorphisms and Lung Cancer Risk in the Chinese Population: a Meta-Analysis Based on 47 Studies

  • Chen, Xin-Ping (College of Agriculture, Hainan University) ;
  • Xu, Wei-Hua (Department of Central Laboratory, the First Affiliated Hospital of Fujian Medical University) ;
  • Xu, Da-Feng (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Fujian Medical University) ;
  • Xie, Xian-He (Department of Chermotherapy, the First Affiliated Hospital of Fujian Medical University) ;
  • Yao, Jia (Department of Breast Surgery, Hainan Province People's Hospital) ;
  • Fu, Sheng-Miao (Department of Central Laboratory, the First Affiliated Hospital of Fujian Medical University)
  • Published : 2014.10.11

Abstract

Although a number of studies have been conducted on the association between GSTM1 polymorphisms and lung cancer in China, this association remains elusive and controversial. To clarify the effects of GSTM1 polymorphisms on the risk of lung cancer, a meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to 5th April 2014. A total of 45 articles (47 studies) including 6,623 cases and 7,865 controls were involved in this meta-analysis. Overall, a significant association (OR = 1.45, 95%CI: 1.32-1.60) was found between the null GSTM1 and lung cancer risk when all studies in Chinese population pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area and source of controls, the same results were observed under all the models. This meta-analysis showed that the null GSTM1 may be a potential biomarker for lung cancer risk in Chinese, but further studies with gene-gene and gene-environment interactions are required for definite conclusions.

Keywords

References

  1. Carlsten C, Sagoo GS, Frodsham AJ, Burke W, Higgins JP (2008). Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis. Am J Epidemiol, 167, 759-74. https://doi.org/10.1093/aje/kwm383
  2. Chan EC, Lam SY, Fu KH, Kwong YL (2005). Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet, 162, 10-20. https://doi.org/10.1016/j.cancergencyto.2005.03.008
  3. Chan Y, Wang X, Wang X, Liang Z (2002). A study of genetic polymorphism of GSTM1 gene in normal population and lung cancer population in Yunnan. J Yunnan Normal Univ, 22, 52-4.
  4. Chan-Yeung M, Tan-Un KC, Ip MS, et al (2004). Lung cancer susceptibility and polymorphisms of glutathione-Stransferase genes in Hong Kong. Lung Cancer, 45, 155-60. https://doi.org/10.1016/j.lungcan.2004.01.016
  5. Chang F, Hu T, Wang G (2006). Relationship between CYP1A1 and GSTM1 genetic polymorphisms and lung cancer susceptibility in population of Inner Mongolia. Zhongguo Fei Ai Za Zhi, 9, 413-7.
  6. Chang F, Wang M, Qi J, et al (2009). Genetic polymorphism of T6235C mutation in 3p non- coding region of CYP1A1 and GSTM1 genes and lung cancer susceptibility in the Mongolian population. Acad J Xi'an Jiaotong University, 21, 225-9.
  7. Chen CM, Jin YT, Xu HY, et al (2012). Effects of CYPlAl and GSTMl gene polymorphisms and BPDE-DNA adducts on lung cancer. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 29, 23-7.
  8. Chen HC, Cao YF, Hu WX, et al (2006). Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China. Dis Markers, 22, 141-52. https://doi.org/10.1155/2006/436497
  9. Chen L, Sun H, Xu M (2003). Study on the allele frequency of GSTM1 gene in normal Han population in Wannan area and the relationship between GSTM1 genotype and the risk of lung cancer. Acta Acad Med Wannan, 22, 13-6.
  10. Chen S, Xu L, Ma J, Wu J, Xue K (1999). Identification of genetic polymorphism of CYP1A1 and GSTM1 in lung cancer patients by using allele-specific PCR and multiplex differential PCR. Carcinogenesis Teratogenesis and Mutagenesis, 11, 119-22.
  11. Chen S, Xue K, Xu L, Ma G, Wu J (2001). Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population. Mutat Res, 458, 41-7.
  12. Du G, Ma D, Tan B, et al (2011). Relationship between genetic polymorphism ofGSTM1 gene and susceptibility to lung cancer in the population of northern Sichuan of China. Chin Clin Oncol, 16, 602-5.
  13. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  14. Fan J, Gan LG, Liang KC, Liang XM (2010). Relationship of GSTM1 and GSTT1 Genetic Polymorphisms with Lung Cancer Susceptibility in Guangxi Zhuang Population. J Oncol, 16, 922-5.
  15. Gao J & Zhang Q (1998). Study on the relationship between GSTM1 polymorphism and lung cancer susceptibility. Carcinogenesis Teratogenesis Mutagenesis, 10, 149-51,.
  16. Gao J, Ren C, Zhang Q (1998). CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility. Chin J Oncol, 20, 185-6.
  17. Gao Y, Zhang Q (1999). Study on the Polymorphisms of GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese. Chin J Public Health, 15, 488-90.
  18. Ge H, Lam WK, Lee J, et al (1996). Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients. Lung Cancer, 15, 355-66. https://doi.org/10.1016/0169-5002(95)00598-6
  19. Gu Y, Zhang S, Lai B, Wang H, Zhan X (2004). Relationship between genetic polymorphism of metabolizing enzymes and lung cancer susceptibility. Zhongguo Fei Ai Za Zhi, 7, 112-7.
  20. Gu YF, Zhang ZD, Zhang SC, et al (2007). Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility. Zhonghua Yi Xue Za Zhi, 87, 3064-8.
  21. Han R, Bai Y, Chang F, et al (2012). GSTM1 gene polymorphism and lung cancer susceptibility in Man population. Central South Pharmacy, 10, 1-4.
  22. Hayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annu Rev Pharmacol Toxicol, 45, 51-88. https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
  23. Hu Y, Gao Y, Zhang Q (1998). Genetic polymorphisms of CYP1A1, CYP2D6 and GSTM1 related with susceptibility to lung cancer. Tumor, 18, 269-71.
  24. Jemal A, Bray F, Center MM, Ferlay F, Ward E, Forman D (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  25. Jin Y, Xu H, Zhang C, et al (2010). Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospitalbased case-control study in China. BMC Cancer, 10, 422. https://doi.org/10.1186/1471-2407-10-422
  26. Kiyohara C, Shirakawa T, Hopkin JM (2002). Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer. Environ Health Prev Med, 7, 47-59. https://doi.org/10.1007/BF02897330
  27. Kriek E, Van Schooten FJ, Hillebrand MJ, et al (1993). DNA adducts as a measure of lung cancer risk in humans exposed to polycyclic aromatic hydrocarbons. Environ Health Perspect, 99, 71-5. https://doi.org/10.1289/ehp.939971
  28. Lan Q, He X, Costa DJ, et al (2000). Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China. Cancer Epidemiol Biomarkers Prev, 9, 605-8.
  29. Lei FM, Li SF, Zhou WD, et al (2007). A case-control study of the impact of Glutathione S-transferase M1 polymorphism on the risk of lung cancer. Mod Prev Med, 34, 724-6.
  30. Li D, Zhou Q, Yuan T, et al (2005). Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer. Zhongguo Fei Ai Za Zhi, 8, 14-9.
  31. Li W, Yue W, Zhang L, et al (2012). Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are associated with susceptibility and chemotherapy response in non-small-cell lung cancer patients. Lung, 190, 91-8. https://doi.org/10.1007/s00408-011-9338-8
  32. Li WY, Lai BT, Zhan XP (2004). The relationship between genetic polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer. Zhonghua Liu Xing Bing Xue Za Zhi, 25, 1042-5.
  33. Li Y, Chen J, Gao Y (2011). Influence of smoking and the polymorphisms of CYP1A1 and GSTM1 on the susceptibility of lung cancer. J Practical Diagnosis and Therapy, 25, 140-3.
  34. Li Y, Tang X, Ma X, Chen J (2005). Glutathione S- transferaseM1 Polymorphisms and Susceptibility to Lung cancer. J Med Forum, 26, 10-2.
  35. Liang G, Pu Y, Yin L (2004). Studies of the Genes Related to Lung Cancer Susceptibility in Nanjing Han Population, China. Hereditas (Beijing), 26, 584-8.
  36. Liang K, Gan L, Ruan Z, et al (2012). Correlation research of the relationship between the genetic polymorphism of GSTM1 and GSTT1 in the Zhuang population and lung cancer. Acta Med Sinica, 25, 813-7.
  37. Liu D, Wang F, Wang Q, et al (2012). Association of glutathione S-transferase M1 polymorphisms and lung cancer risk in a Chinese population. Clin Chim Acta, 414, 188-90. https://doi.org/10.1016/j.cca.2012.09.016
  38. Liu Q, Liu J, Song B, Wang ZH (2008). Relationship between susceptibility to lung lancer and genetic polymorphism in CYP1A1 and GSTM1. Shandong Med J, 48, 32-4.
  39. London SJ, Yuan JM, Chung FL, et al (2000). Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet, 356, 724-9. https://doi.org/10.1016/S0140-6736(00)02631-3
  40. Lu KQ (2013). Study on the association between GSTMl gene polymorphism and lung cancer. Capital Med, 12, 25-7.
  41. Lu W, Xing D, Qi J, et al (2002). Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population. Int J Cancer, 102, 275-9. https://doi.org/10.1002/ijc.10712
  42. Luo C, Chen Q, Cao W, Chen S (2004). Combined analysis of polymorphisms of GSTM1 and mutations of p53 gene in the patients with lung cancer. Chin J Clin Oncol, 31, 1218-20.
  43. Ma D, Du G, Tan B, et al (2013). Study on genetic polymorphism of GSTM1 and GSTT1 related with susceptibility to lung cancer in the Population of Northern Sichuan of China. Sichuan J Cancer Control, 26, 136-9.
  44. McIlwain CC, Townsend DM, Tew KD (2006). Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene, 25, 1639-48. https://doi.org/10.1038/sj.onc.1209373
  45. Neumann AS, Sturgis EM, Wei QY (2005). Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. Mol Carcinog, 42, 65-92. https://doi.org/10.1002/mc.20069
  46. Piao JM, Shin MH, Kim HN, et al (2013). Glutathione-Stransferase (GSTM1, GSTT1) null phenotypes and risk of lung cancer in a Korean population. Asian Pac J Cancer Prev, 14, 7165-9. https://doi.org/10.7314/APJCP.2013.14.12.7165
  47. Qian B, Han H, Gu F, et al (2006). Case-Control Study Genetic Polymorphism in CYP1A1 and GSTM1 and Smoking and Susceptibility to Lung Cancer. Chin J Clin Oncol, 33, 500-2.
  48. Qiao GB, Sun CS, Li LS, Zeng WS, Jiang RC (2005). A casecontrol study on relationship between absence of GSTM1 gene, smoking and susceptibility to non-small cell lung cancer. J Fourth Mil Med Univ, 26, 1008-10.
  49. Seidegard J, Pero RW, Miller DG, et al (1986). A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis, 7, 751-3. https://doi.org/10.1093/carcin/7.5.751
  50. Shi X, Zhou S, Wang Z, Zhou Z, Wang Z (2008). CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. Lung Cancer, 59, 155-63. https://doi.org/10.1016/j.lungcan.2007.08.004
  51. Shukla RK, Tilak AR, Kumar C, et al (2013). Associations of CYP1A1, GSTM1 and GSTT1 polymorphisms with lung cancer susceptibility in a Northern Indian population. Asian Pac J Cancer Prev, 14, 3345-9. https://doi.org/10.7314/APJCP.2013.14.5.3345
  52. Song B, Liu J, Huang H, et al (2010). Effects of metabolic enzyme CYP1A1 and GSTM1 gene polymorphisms and smoking factors on the occurrence of male lung squamous cell carcinoma. Basic & Clin Med, 30, 1193-6.
  53. Vineis P & Husgafvel-Pursiainen K (2005). Air pollution and cancer: biomarker studies in human populations. Carcinogenesis, 26, 1846-55. https://doi.org/10.1093/carcin/bgi216
  54. Wang D, Chen S, Wang B, Cai X, Xian X (2006). A case control study on relationship between lung cancer and genetic polymorphism of CYP1A1, CYP2E1 and GSTM1 in Han Nationality, in Guangzhou Area. Bull Chin cancer, 15, 579-82.
  55. Wang D, Chen S, Wang B, Zhou W (2007). Interaction between smoking and polymorphism of GST in lung cancer. Chin Prev Med, 8, 466-7.
  56. Wang J, Deng Y, Cheng J, Ding J, Tokudome S (2003). GST genetic polymorphisms and lung adenocarcinoma susceptibility in a Chinese population. Cancer Lett, 201, 185-93. https://doi.org/10.1016/S0304-3835(03)00480-4
  57. Wang J, Deng Y, Li L, et al (2003). Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population. Cancer Sci, 94, 448-52. https://doi.org/10.1111/j.1349-7006.2003.tb01463.x
  58. Wang MJ, Chang FH, Yin Q, Qi J, Wang G (2009). Relationship of GSTM1 polymorphism and lung cancer susceptibility in Mongolian population. Chin J Public Health, 25, 1447-8.
  59. Wang N, Wu YJ, Zhou XL, Wu YM (2012). Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population. J Hygiene Res, 41, 251-6.
  60. Wang N, Zhuang D, Wu Y (2005). Research on relationship between GSTM1 gene deletion and lung cancer genetic susceptibility. J Henan Univ Sci Tech, 23, 7-8.
  61. Wang Q, Lu Q, Zhen H, Bao M, Zhang H (2006). Relationship between CYP2C9 and GST M1 genetic polymorphism and lung cancer susceptibility. Cancer Res Prev Treat, 33, 8-10.
  62. Wells GA, Shea B, O'Connell D, et al (2009). The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Available from: www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
  63. Wu CL, Chen SD, Lin GP, et al (2003). A case-control study on relationship between polymorphisms of CYP1A1, GSTM1 and lung cancer. South China J Prev Med, 29, 13-6.
  64. Xia Y, Sun QF, Shang B, et al (2008). Polymorphisms of the cytochrome P450 and glutathione S-transferase genes associated with lung cancer susceptibility for the residents in high radon-exposed area. Chin J Radiol Med Prot, 28, 327-32. https://doi.org/10.1088/0952-4746/28/3/003
  65. Xian X, Chen S, Wang B (2003). The relationship between polymorphism of GSTM1 and susceptibility to lung cancer. Pract Prev Med, 10, 635-7.
  66. Xue K, Xu L, Chen S, Ma J, Wu J (2001). Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 18, 125-7.
  67. Yang XR, Wacholder S, Xu Z, et al (2004). CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women. Cancer Lett, 214, 197-204. https://doi.org/10.1016/j.canlet.2004.06.040
  68. Yao W, Wang N, Wu YJ, Wu YM (2006). Relationshipbetween deletion of GSTM1, GSTT1 genes and susceptibility to lung cancer. Chin J Public Health, 22, 1070-72.
  69. Yao Z, E Y, Wang H (2012). The interacted effects between glutathione s-transferase gene polymorphism and smoking in lung cancer. Chin J Med Guide, 14, 185-6.
  70. Ye W, Chen S, Chen Q (2005). Interaction between serum selenium level and polymorphism of GSTM1 in lung cancer. Acta Nutrimenta Sinica, 27, 17-20.
  71. Zeng M, Chen S, Xie C, et al (2005). Case control study on relationship between lung cancer and its susceptibility marker. Chin J Public Health, 21, 771-4.
  72. Zhang J, Hu Y, Hu C, Wang S (2002). Relationship between genetic polymorphisms of GSTM1 as well as GSTT1 and lung cancer. Chin J Pathophysiology, 18, 352-5.
  73. Zhang J, Hu Y, Hu C, Wang S (2002a). Study on genetic polymorphisms of GSTM1 and GSTT1 related with inherent susceptibility to lung cancer in women. Chin J Public Health, 18, 273-5.
  74. Zhang J, Long X, Xiong G, et al (2011). The Relationship between Glutathione S-transferase M1 and Susceptibility to Xuanwei's Lung Cancer. J Kunming Med Univ, 32, 56-8.
  75. Zhang L, Wang X, Hao X, Shi Y, Liu Z (2002). Relationship between susceptibility to lung cancer and genetic polymorphism in P4501A1, GSTM1. Chin J Clin Oncol, 29, 536-40.
  76. Zhao B, Seow A, Lee EJ, et al (2001). Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol Biomarkers Prev, 10, 1063-7.
  77. Zheng D, Hua F, Mei C, Wan H, Zhou Q (2010). Association between GSTM1 genetic polymorphism and lung cancer risk by SYBR green I Real-time PCR Assay. Zhongguo Fei Ai Za Zhi, 13, 506-10