Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran

  • Mansour-Ghanaei, Fariborz (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Joukar, Farahnaz (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Rajpout, Yaghoub (Internal Medicine Department, Jahrom University of Medical Sciences) ;
  • Hasandokht, Tolou (Community Medicine Department, Guilan University of Medical Sciences)
  • Published : 2014.10.11
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Abstract

Background: The aim of this study was to investigate the value of serum gastric markers to differentiate between patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serum samples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested for pepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson's correlation analyses were used for analysis using SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerous lesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) different between the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markers for screening of premalignant gastric lesions.

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References

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