Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Mutagenicity of Lithium Carbonate Assessed by Bacterial Reverse Mutation(Ames) Test

미생물복귀돌연변이(Ames)시험을 통한 탄산리튬의 변이원성 고찰

  • Rim, Kyung-Taek (Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Kim, Soo-Jin (Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency)
  • 임경택 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김수진 (한국산업안전보건공단 산업안전보건연구원)
  • Received : 2014.02.17
  • Accepted : 2014.08.08
  • Published : 2014.09.30
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Abstract

Objectives: To evaluate the mutagenicity of lithium carbonate, a bacterial reverse mutation(Ames) test was carried out using four strains of S. typhimurium(TA1535; TA1537; TA98; and TA100) and one strain of E. coli(WP2uvrA). Materials: This was carried out in a dose range from 312.5 to $5,000{\mu}g/plate$ in triplicate with and without S9 activation, which is the most commonly used metabolic activation system supplemented by a post-mitochondrial fraction prepared from the livers of rodents treated with enzyme-inducing agents such as Aroclor 1254 or a combination of phenobarbitone and ${\beta}$-naphthoflavone. Results: No significant increases in the number of revertants were observed under the conditions examined in this study. Conclusions: Based on the above observations, it can be concluded that lithium carbonate has no mutagenic activity. Despite the results, it can have an effect by inducing acute oral toxicity, eye irritation and acute aquatic toxicity. Based on this study, we suggest that future studies should be directed toward chronic, carcinogenic testing and other related areas.

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References

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