The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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$H_2$ Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)

  • Lee, Sang Eok (Department of Surgery, Konyang University Hospital) ;
  • Kim, Dae Hoon (Department of Surgery, Chungbuk National University College of Medicine) ;
  • Kim, Young Chul (Department of Physiology, Chungbuk National University College of Medicine) ;
  • Han, Joung-Ho (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Choi, Woong (Department of Pharmacology, Chungbuk National University College of Medicine) ;
  • Kim, Chan Hyung (Department of Pharmacology, Chungbuk National University College of Medicine) ;
  • Jeong, Hye Won (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Park, Seon-Mee (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Yun, Sei Jin (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Choi, Song-Yi (Department of Pathology, Chungnam National University School of Medicine) ;
  • Sung, Rohyun (Department of Pathology, Chungbuk National University College of Medicine) ;
  • Kim, Young Ho (Department of Otolaryngology, Seoul National University, Borame Medical Center) ;
  • Yoo, Ra Young (Department of Physiology, Chungbuk National University College of Medicine) ;
  • Park, Hee Sun (Department of Physiology, Chungbuk National University College of Medicine) ;
  • Kim, Heon (Department of Preventing Medicine, Chungbuk National University College of Medicine) ;
  • Song, Young-Jin (Department of Surgery, Chungbuk National University College of Medicine) ;
  • Xu, Wen-Xie (Department of Physiology, College of Medicine, Shanghai Jiaotong University) ;
  • Yun, Hyo-Yung (Department of Surgery, Chungbuk National University College of Medicine) ;
  • Lee, Sang Jin (Department of Physiology, Chungbuk National University College of Medicine)
  • Received : 2014.07.02
  • Accepted : 2014.07.21
  • Published : 2014.10.30
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Abstract

This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced tonic relaxation in a concentration-dependent and reversible manner, although histamine enhanced contractility in a minor portion of tissues tested. Histamine-induced tonic relaxation was nerve-insensitive because pretreatment with nerve blockers cocktail (NBC) did not inhibit relaxation. Additionally, $K^+$ channel blockers, such as tetraethylammonium (TEA), apamin (APA), and glibenclamide (Glib), had no effect. However, $N^G$-nitro-L-arginine methyl ester (L-NAME) and 1H-(1,2,4)oxadiazolo (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC), did inhibit histamine-induced tonic relaxation. In particular, histamine-induced tonic relaxation was converted to tonic contraction by pretreatment with L-NAME. Ranitidine, the $H_2$ receptor blocker, inhibited histamine-induced tonic relaxation. These findings suggest that histamine produced relaxation in circular smooth muscle of human gastric smooth muscle through $H_2$ receptor and NO/sGC pathways.

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References

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